The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces lung tumors in rats, mice, and hamsters, and metabolic activation is required for the carcinogenicity. 2-Phenethyl isothiocyanate (PEITC), whose precursor gluconasturtiin (a glucosinolate) occurs in cruciferous vegetables, has been found to inhibit carcinogenesis by NNK. The purpose of the study was to ...

Coronavirus disease 2019 (COVID-19) is currently receiving the whole world's attention. It appeared first in Wuhan city of China and rapidly spread to world, causing many mortalities morbidities; mainly transmitted via respiratory droplets has a long infectivity period about 14 days. Science shows that virus also skin if by any means finds its way land on surface. Infection occurs when touching...

Stool is chemically complex and the extraction of DNA from stool samples is extremely difficult. Haemoglobin breakdown products, such as bilirubin, bile acids and mineral ions, that are present in the stool samples, can inhibit DNA amplification and cause molecular assays to produce false-negative results. Therefore, stool storage conditions are highly important for the diagnosis of intestinal ...

The Federal Panel on Formaldehyde concluded that definitive experiments exist which demonstrate the mutagenicity and carcinogenicity of formaldehyde under laboratory conditions. Formaldehyde induces both gene mutations and chromosomal aberrations in a variety of test systems. Inhalation of formaldehyde causes cancer of the nose in rats. The concentrations of formaldehyde in inhaled air that cau...

Formaldehyde is used in the production of resins, molding compounds, photographic film, bactericide, and tissue preservative. The purpose of this study was to provide an up-to-date critical review of the information to the toxicological profile of formaldehyde, and to assess the risk of formaldehyde for the general population in Japan. Inhaled formaldehyde is an effective sensory irritant at a ...

Formaldehyde is the illegal chemical substance used for food preservation in fish and vegetable. It can promote carcinogenesis. Superoxide dismutases are the important antioxidative enzymes that catalyze the dismutation of superoxide anion into oxygen and hydrogen peroxide. The resultant level of oxidative stress in formaldehyde-treated lymphocytes was investigated. The formaldehyde concentrati...

Formaldehyde is the simplest of all aldehydes and is highly cytotoxic. Its use and associated dangers from environmental exposure have been well documented. Detoxification systems for formaldehyde are found throughout the biological world and they are especially important in methylotrophic bacteria, which generate this compound as part of their metabolism of methanol. Formaldehyde metabolizing ...

The isotopic composition of dihydrogen generated from formaldehyde in highly basic solutions has been investigated. It is shown that two pathways contribute to the generation of dihydrogen. In the f i s t pathway, one hydrogen atom originates from water and the other from formaldehyde. In the second pathway both hydrogen atoms originate from the methylene moiety of the formaldehyde. For product...