Both W9 and OP3-4 were known to bind the receptor activator of NF-κB ligand (RANKL), inhibiting osteoclastogenesis. Recently, both peptides were shown to stimulate osteoblast differentiation; however, the mechanism underlying the activity of these peptides remains to be clarified. A primary osteoblast culture showed that rapamycin, an mTORC1 inhibitor, which was recently demonstrated to be an i...

A new biological active hexapeptide of C-terminal of nocistatin, contains Glu-Gln-Lys-Gln-Leu-Gln sequence was synthesized according to solid phase peptide synthesis on the surface of 2-chloro tritylchloride resin and using fmoc-protected amino acids in the presence of TBTU (O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyl uranium tetrafluoroborate) as a coupling reagent. Then, amidation of the C-te...

Microenvironmental factors may influence the antioxidant efficacy of food-derived peptides. This study evaluated in vitro properties peptides released during ripening (9 to 24 months processing) Spanish dry-cured ham (Biceps femoris muscle) assisted by spectral-chromatographic methodologies. Results indicated that 2,2?-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical-cation (ABTS?+) qu...

Tumor-targeted therapies are playing growing roles in cancer research. The exploitation of these powerful therapeutic modalities largely depends on the discovery of tumor-targeting ligands. Phage display has proven a promising high throughput screening tool for the identification of novel specific peptides with high binding affinity to cancer cells. In the present study, we describe the use of ...

Outside Front Cover: Peptides undergo chemical modifications similar to post-translational in living organisms under plasma treatment, which play a key role protein function. We present modeling study on the interactions of and peptides by Reactive Molecular Dynamic (RMD) simulation. The formation breaking bonds generation new reactive groups structure are investigated upon impact oxygen specie...

introduction: scorpion venom is a source of bioactive peptides, and some antimicrobial peptides (amps) have been found in the venom gland of scorpions. therefore, the discovery of new anti-infective agents is an essential need to overcome the problem of antibiotic resistance of clinical isolates. here, we describe three new cationic amps, including meuvap-6, meuap-18-1, and meupep34 from the ve...