P of variation in nature have played a large role in the development of explanations for biological richness at the species level. One such inf luential pattern has been the morphological distinctiveness of small populations on islands at the periphery of a large continental land mass (1). If the island differs from the mainland in habitat or composition of the biological community, the morphol...

BACKGROUND Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is an autosomal recessive tubular disease caused by mutations in the CLDN16 or CLDN19 gene. Previous studies using microsatellite markers flanking the CLDN19 locus estimated that p.G20D (c.59G>A), a recurrent mutation in Spanish families, is a founder mutation. In the present study, we assessed the haplotype of ...

We present a very flexible method that allows us to analyze X-linked quantitative trait loci (QTL) in crosses between outbred lines. The dosage compensation phenomenon is modeled explicitly in an identity-by-descent approach. A variety of models can be fitted, ranging from considering alternative fixed alleles within the founder breeds to a model where the only genetic variation is within breed...

When populations colonize new areas, both strong selection and drift can be experienced due to novel environments small founding populations, respectively. Empirical studies have predominantly focused on the phenotype when assessing role of selection, limited neutral-loci founder-induced loss diversity. Consequently, extent which processes interact influence evolutionary trajectories is difficu...

It is thought that at least some of the initial specification of the five somatic founder cells of the C. elegans embryo occurs cell-autonomously through the segregation of factors during cell divisions. It has been suggested that in embryos from mothers homozygous for mutations in the maternal-effect gene mex-1, four blastomeres of the 8-cell embryo adopt the fate of the MS blastomere. It was ...