Fragile X syndrome, diagnosed by Fragile X Mental Retardation 1 (FMR1) DNA testing, is the most common single-gene cause of inherited intellectual disability. The expanded CGG mutation in the FMR1 gene, once thought to have clinical significance limited to fragile X syndrome, is now well established as the cause for other fragile X-associated disorders including fragile X-associated primary ova...

Three major aspects in the protection of digital documents have been pointed out, each of them with di erent requirements: rst copyright protection, protecting ownership and usage rights; secondly tamper-proo ng, aiming at checking document integrity; and thirdly authentication, the purpose of which is to check the authenticity of a document. While robust watermarks are typically used for copyr...

Nearly 15 years ago, female carriers of the fragile X mental retardation syndrome were noted to have an increased incidence of twin pregnancies. Since then, much evidence has accumulated supporting the notion of ovarian dysfunction in fragile X carriers, in the forms of increased dizygotic twinning and premature ovarian failure. However, despite a decade and a half of research regarding this as...

Fragile X Syndrome, the most common form of inherited mental retardation, is characterized by autistic behavior and mild to severe learning disabilities. The disease is caused by the expansion of a trinucleotide repeat located on the FMR1 (Fragile X Mental Retardation) gene located on the Xchromosome. Since the early 1990s, 348 prenatal female samples have been analyzed for Fragile X Syndrome a...

This paper summarises research on aid allocation and effectiveness, highlighting the current findings of recent research on aid allocation to fragile states. Fragile states are defined by the donor community as those with either critically poor policies or poorly performing institutions, or both. The paper examines the research findings in the broader context of research and analysis on how aid...

A hybrid watermark that consists of a robust part and a fragile part can be used to serve multiple purposes. The robust part can protect copyright information, the fragile part can detect tampering, and their combination enables identification of attacks encountered. This paper analyses an overlap and a non-overlap implementation of the robust and fragile parts in a hybrid system. The differenc...

Fragile sites are heritable specific chromosome loci that exhibit an increased frequency of gaps, poor staining, constrictions or breaks when chromosomes are exposed to partial DNA replication inhibition. They constitute areas of chromatin that fail to compact during mitosis. They are classified as rare or common depending on their frequency within the population and are further subdivided on t...

OBJECTIVE To provide Canadian family physicians, genetic counsellors, medical geneticists, midwives, and obstetrician-gynaecologists with recommendations regarding screening for fragile X in the obstetrical and gynaecological population. METHODS Medline, the Cochrane Library, journals, and textbooks were searched for English-language articles, published between 1966 and March 2008, relating t...

Fragile X syndrome occurs as a result of a mutation of the fragile X mental retardation 1 (FMR1) gene on the bottom of the X chromosome (Pic. 1), which encodes fragile X mental retardation protein (FMRP). This protein, most commonly found in the brain, is essential for normal cognitive development and female reproductive function. The CGG triplet that means gene segment consisting of a cytosine...

One limitation for the study of chromosomal fragile sites is that they must be studied on metaphase spreads, after the breakage. We show here that bacterial lac operator (lacO) repeats are prone to spontaneous breakage, which when combined with a fluorescent lac repressor (lacR) has allowed us to track a fragile site through the cell cycle. By using this system, we show that Plk1-interacting ch...