National Heart, Lung, and Blood Institute’s Framingham Heart Study (CSL, MGL, EJB, RSV), Framingham, MA; Department of Biostatistics (XL, QY, MJP) and Epidemiology (EJB), Boston University School of Public Health, Boston, MA; Department of Mathematics and Statistics, Boston University, Boston, MA (MGL); Harvard Medical School, Boston, Mass (JA); Mayo Clinic, Rochester, MN (MMR, CSL), Cardiology...

1 Genetics Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 2 National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, MA 3 Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Department of Pathology, Beth Israel Deaconess Hospital, Harvard Medical School Harvard Stem C...

Conall M. O’Seaghdha* and Caroline S. Fox*** *National Heart, Lung, and Blood Institute’s Framingham Offspring Study and the Center for Population Studies, Framingham, Massachusetts; Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland; Renal Division and Division of Endocrinology, Brigham and Women’s Hospital, Boston, Massachusetts; Renal Division, Mas...

OBJECTIVE To examine the validity of estimates of coronary heart disease (CHD) risk by the Framingham risk function, for European populations. DESIGN Comparison of CHD risk estimates for individuals derived from the Framingham, prospective cardiovascular Münster (PROCAM), Dundee, and British regional heart (BRHS) risk functions. SETTING Sheffield Hypertension Clinic. Patients-206 consecutiv...

BACKGROUND AND PURPOSE We examined the 20-or-more-year survival and functional levels of 148 stroke survivors and 148 age- and sex-matched control subjects from the Framingham Study Cohort, whom we originally studied in 1972-1974 to ascertain the survival and disability status of stroke survivors compared with that of controls. METHODS This long-term evaluation was done with use of data from ...

A promising hypertension risk prediction score using data from the US Framingham Offspring Study has been developed, but this score has not been tested in other cohorts. We examined the predictive performance of the Framingham hypertension risk score in a European population, the Whitehall II Study. Participants were 6704 London-based civil servants aged 35 to 68 years, 31% women, free from pre...

A promising hypertension risk prediction score using data from the US Framingham Offspring Study has been developed, but this score has not been tested in other cohorts. We examined the predictive performance of the Framingham hypertension risk score in a European population, the Whitehall II Study. Participants were 6704 London-based civil servants aged 35 to 68 years, 31% women, free from pre...

Cardiovascular disease is increased in HIV-infected patients. Cytokines such as osteoprotegerin are implicated in atherosclerosis. The aim of our study was to evaluate the role of osteoprotegerin in the development and progression of atherosclerosis in HIV infected subjects on suppressive antiretroviral treatment. We enrolled 76 patients; 35 HIV infected men on suppressive Highly Active Antiret...

We compared markers of glucose homeostasis and their association with diabetes and impaired fasting glucose (IFG) in Fukuoka, Japanese subjects (n = 1108) and age-, gender- and menopausal status-matched participants in the Framingham Offspring Study (n = 1096). The markers examined included fasting glucose, insulin, adiponectin, and glycated albumin, as well as body mass index (BMI), use of med...

UNLABELLED Aims/Introduction:  Visceral obesity has been suggested to be an independent risk factor for cardiovascular disease (CVD); the role of adipokines in the risk for CVD is less clear. Aim of this study was to investigate the relationship between parameters of visceral obesity and index of CVD risk factors. MATERIALS AND METHODS   A cross-sectional analysis of healthy males (n = 116) a...