نتایج جستجو برای: franz cell diffusion
تعداد نتایج: 1833469 فیلتر نتایج به سال:
In this study, we examined and compared two different lipid-based nanosystems (LBNs), namely Transferosomes (TFs) Monoolein Aqueous Dispersions (MADs), as delivery systems for the topical application of Ferulic Acid (FA), an antioxidant molecule derived from natural sources. Our results, demonstrated through Franz-cell experiments, indicate that LBNs produced with poloxamer 188 in their composi...
Purpose: To investigate the penetration enhancing effect of two polysorbates polyoxyethylene 20 (POE-20) and polyoxyethylene 80 (POE-80) on the in vitro percutaneous absorption of ascorbic acid (AA). Methods: For the permeation experiments, Franz diffusion cell covered with aluminum foil providing an effective diffusion area of 1.76 cm 2 and hairless rabbit skin were used. A range of concentrat...
PURPOSE In vitro skin/membrane permeation profiling of topical pharmaceuticals is an important overall quality attribute in the evaluation of product consistency and it is also used for IVIVR (in vitro - in vivo relationship) purposes in product development and change control. Franz diffusion cell (FDC) experiments are emerging as a generally accepted methodology in this field, where the choice...
Franz Peherstorfer was born in Zwettl an der Rodl, a village near Linz, the provincial capital of Upper Austria. After attending elementary and secondary schools in and around Linz, he matriculated in the newly founded Johannes Kepler Universität Linz1 in 1970 where he obtained his university degrees, Masters (1975) and Ph.D.2 (1977), both with summa cum laude. He was appointed as Assistent the...
The skin penetration and safety of nanometric zinc oxide and titanium dioxide incorporated in a cosmeceutical cream, specifically designed to retard skin actinic damage in tropical Oculocutaneous albinism was investigated ex-vivo through simulated actinically damaged porcine skin. Franz diffusion cells were used in an experiment modeled in line with related work done by Diembeck et al (1999); t...
Pathogens usually invade hair follicles when skin infection occurs. The accumulated bacteria in follicles are difficult to eradicate. The present study aimed to assess the cutaneous and follicular delivery of chloramphenicol (Cm)-loaded liposomes and the antibacterial activity of these liposomes against methicillin-resistant Staphylococcus aureus (MRSA). Skin permeation was conducted by in vitr...
The possibility of applying liposomes as a topical drug delivery system is still a matter of intensive research. The purpose of this study was to determine the suitability of liposomes as carriers of naproxen and to prove their impact on the effectiveness of transdermal permeation of an active substance. The study was conducted with the use of Franz Diffusion Cell System by comparing the effica...
In the present study, an attempt was made to develop a low-dose controlled-release delivery system for the treatment of periodontal infections. Nylon fibres were taken as core material. The coating solution contained polyvinyl acetate and amoxycillin trihydrate. The fibres were coated five times to maximize drug loading. The coating composition was optimized and fibres were subjected to in vitr...
Purpose To determine in vitro release profiles, transcorneal permeation, and ocular injection characteristics of a voriconazole-containing thermogel suitable for injection into the subconjunctival space (SCS). Methods In vitro release rate of voriconazole (0.3% and 1.5%) from poly (DL-lactide-co-glycolide-b-ethylene glycol-b-DL-lactide-co-glycolide) (PLGA-PEG-PLGA) thermogel was determined fo...
BACKGROUND Development of new drug carriers would be an interesting approach if it allowed increased efficacy of antibiotics and a reduction in doses, thus reducing the risk of developing resistance. As with most drug carriers, niosomes have been used to improve the selective delivery and the therapeutic index of antimicrobial agents. METHODS In this study, different formulation of niosomes c...
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