ischemia has an important role in spread of pathologic injuries in the neuropathies. it is widely accepted that most damages such as reperfusion injuries, are related to the activity of free radicals. apoptotic signaling was exacerbated by free radicals. the aim of this study was to evaluate the neuroprotective effect of human chorionic gonadotropin (hcg) and vitamin e (trolox) in the hippocamp...

The glycoprotein hormones are a family of conserved heterodimeric proteins which share a common alpha subunit but differ in their hormone-specific beta subunits. We used chimeras of human chorionic gonadotropin (hCG) and luteinizing hormone (hLH) beta subunits to identify residues which enable monoclonal antibodies (mAb) to distinguish the two hormones. The LH beta-CG beta chimeras appeared to ...

BACKGROUND Several studies have indicated that cryptorchidism is associated with degenerative changes in both Sertoli cells and germ cells. The gonadal peptide hormone inhibin B reflects Sertoli cell function. Low inhibin B levels are found in a large portion of formerly cryptorchid men who show compromised seminiferous tubule function. It is not known if inhibin B can be used to demonstrate ea...

BACKGROUND Solitary fibrous tumors are rare tumors of mesenchymal origins, most commonly seen arising from the pleural lining of the lungs. These are generally benign tumors, which in rare cases have been identified to be associated with multiple para-neoplastic syndromes. CASE REPORT This is a case of a solitary fibrous tumor of the pleura in a 49 year old female which was found to be associ...

BACKGROUND Approximately two million pregnancies in the United States are screened for Down syndrome annually by use of second-trimester maternal serum markers. At present, a combination of four markers can identify 75% of affected pregnancies when 5% of screened women are classified as candidates for amniocentesis. Although not currently included in screening panels, invasive trophoblast antig...

Total human chorionic gonadotropin (hCG-hCG beta) in serum was assayed with the immulite system, a fully automated random-access immunoassay analyzer that has a unique centrifugal procedure for solid-phase washing and a chemiluminescent detection system. The broad range of the hCG calibration curve (up to 5000 IU/L) is achieved by using a small serum sample size (5 microL), which provides suffi...

Methotrexate (MTX) is an accepted regimen for conservative treatment of unruptured ectopic pregnancy. However ,gestational sac greater than 3.5 cm, existence of cardiac activity and high titers of serum beta human chorionic gonadotrophin ( B-HCG) levels are relative contraindications of Mtx treatment. A 29-year-old, gravida 3, parity 1 and a 34-year-old nulliparous women presented with a compla...

We recently showed that endometrial tissue produces hCG during the secretory phase of the menstrual cycle. Based on these findings, we hypothesized that the decidua should also be able to secrete hCG. We examined the decidualized endometrium of patients with extrauterine pregnancies. Decidual specimens were obtained for mRNA extraction and paraffin embedding from 24 patients that were between w...