plagiocephaly (oblique skull) is premature fusion of one of the coronal sutures. frontal plagiocephaly is a rare congenital deformity in the skull that is the most complicated form of craniosynostosis to treat. examination of all sutures is necessary for diagnosis of craniosynostosis in this article, a 10-month-old, healthy girl with deformity of the right forehead and orbit that is caused by f...

renal cell carcinoma comprises about 2% of adult tumors. the overall 10-year survival rate of patients with rcc after nephrectomy is about 18-27%. the incidence of metastasis of initial rcc is about 24-28%, but this rate after nephrectomy is as high as 51%. the most common site of recurrence is the lung, however liver and bone metastases are common. there are many reported cases with late metas...

conclusions surgeons should consider the possibility of existence of other mucoceles when they find a large downstream sinus mucocele obstructing the ostia of upstream sinuses on computed tomography scans. introduction mucoceles of the paranasal sinuses are relatively rare. a very busy otolaryngology department does not have more than a few cases each year. bilateral, multiple, and multiloculat...

introduction: alzheimer’s disease (ad) is one of the most common neurodegenerative disorders, which has much benefited from animal models to find the basics of its pathophysiology. in our previous work (haghani, shabani, javan, motamedi, & janahmadi, 2012), a non-transgenic rat model of ad was used in electrophysiological studies. however, we did not investigate the histological aspects in the ...

the adhesive interaction between tumor cells and the host cells or the extracellular matrix plays a crucial role in tumor metastasis. to evaluate the mediation of cell adhesion by daphne mucronata, an anti-cancer medicinal plant in iranian folk medicine, the adhesion of thrombin activated human platelets to the cultured monocytes or hl-60 cells was investigated under the effect of the plant ext...

purpose: to report a case of metastatic tumor to the right upper eyelid originating from a lung adenocarcinoma without any systemic signs. case report: a 68-year-old man had a two-month history of painless swelling in the right upper eyelid. the tumor slowly grew. two years before his presentation, he had received chemotherapy for lung cancer for one year. systemic and ocular examinations were ...

background: metastasis is one the most leading cause of death from cancer. the chemokine receptor of cxcr4 has an important role in cell migration and cancer metastasis. additionally, metastasis is always associated with the process of epithelial-mesenchymal transition (emt). in this study the correlation between expression of cxcr4 and emt-tfs has been examined. methods: the expression of cxcr...

despite the high rate of prostate cancer, the incidence of penile metastasis originating from prostate cancer is extremely rare, especially in the form of peyronie’s disease. moreover, brain metastasis, which is caused by prostate cancer, is not a common phenomenon and occurs mostly in older patients. herein, we report a case of a middle-aged man with penile and brain metastasis originating fro...

it has been reported that cxcl12 binding to cxcr4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on mcf-7 and mda-mb-23...