The social use of ecstasy (methylenedioxymethampheta-mine, MDMA) and amphetamines is widespread in the UK and Europe, and they are popularly considered as 'safe'. However, deaths have occurred and hepatotoxicity has featured in many cases of intoxication with amphetamine or its methylenedioxy analogues such as ecstasy. Recreational use of these drugs presents an important but often concealed ca...

The role of liver transplantation in 29 patients with fulminant and subacute hepatic failure due to a variety of different causes was examined by comparing the outcome and a variety of "hospitalization" variables. Transplanted patients (n = 13) were more likely to survive (p less than 0.05), were younger (p less than 0.05) and spent more time in the hospital (p less than 0.025) than did those w...

Ingestion of the mushroom containing Amanita phalloides can induce fulminant liver failure and death. There are no specific antidotes. Blood purifications, such as molecular adsorbent recirculating system (MARS) and therapeutic plasma exchange (TPE), are potential therapies. However, the extent to which these technologies avert the deleterious effects of amatoxins remains controversial; the opt...

wilson's disease is a rare but treatable condition with variable clinical presentations. its diagnosis depends on a combination of clinical and laboratory findings. we evaluated the clinical and laboratory findings in children with wilson's disease (wd). twenty -seven children (4-14 years, 59.2 % male, 40.7% female) with confirmed wd were evaluated between 1994 and 2003 at imam khomei...

Jaundice in pregnancy can be caused by viral hepatitis, intrahepatic cholestasis of pregnancy, choledocholithiases, HELLP syndrome (hemolysis, elevated liver enzymes, and a low platelet count), severe preeclampsia, and acute fatty liver of pregnancy. I Acute fatty liver of pregnancy occurs in approximately 1 in 13,000 pregnancies. More than 90% of patients with acute fatty liver of pregnancy ha...

M l T p c s e m t e a a s s b c o s c p nd-stage liver disease is the tenth most frequent cause f death in the US, causing approximately 25,000 deaths nnually. Although only about 2,000 cases of acute liver ailure occur each year in the US, the mortality rate emains as high as 28%. The application of orthotopic iver transplantation to acute and fulminant hepatic failre has increased the surviva...

To cite: Cheung VTF, Singanayagam J, Molyneux A, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2015212522 DESCRIPTION A 54-year-old man presenting with dysphagia, weight loss, epigastric pain and cervical lymphadenopathy was referred directly to endoscopy. The medical history included hypertension and hypercholesterolaemia. Blood tests showed normal bilir...

Objective. To present a case of a healthy 41-year-old female who developed fulminant hepatic failure leading to death. The cause of hepatic failure identified on postmortem exam was herpes simplex virus hepatitis. Design. Observation of a single patient. Setting. Intensive care unit of a tertiary care university teaching hospital in Canada. Patient. 41-year-old previously healthy female present...

Six cases of severe jaundice and encephalopathy due to falciparum hepatitis initially diagnosed as fulminant hepatic failure are reported. This rare presentation of falciparum malaria should be suspected in patients with persistent fever, jaundice, encephalopathy and hepatomegaly. The diagnosis should be further suspected when the liver function tests show a predominantly conjugated hyperbiliru...

OBJECTIVE To determine the etiology, clinical features and outcome of fulminant hepatic failure in pregnancy. METHODS An observational hospital based study was conducted at Isra University hospital Hyderabad from 1st March 2009 to 28th February 2010. Total 1192 obstetric patients were admitted in obstetrics & gynaecology department during this period, of whom 52 were with Fulminant hepatic fa...