Irritable bowel syndrome (IBS) is a functional gut disorder with high prevalence. Because of various factors involved in its pathophysiology and disappointing results from conventional IBS medications, the treatment of IBS is challenging and use of complementary and alternative medicines especially herbal therapies is increasing. In this paper, electronic databases including PubMed, Scopus, and...

Fumaric Acid Esters (FAE) are found naturally in some plants (Fumaria officinalis) and mushrooms. In Germany, a mixture of fumaric acid esters (Fumaderm®) is licensed for the treatment of psoriasis [1]. A clinical formulation of dimethyl fumarate (referred to as gastro-resistant Dimethyl Fumarate (DMF) or delayed-release DMF) is approved in the United States, New Zealand, Australia, European Un...

Currently, >35 Saudi Arabian medicinal plants are traditionally used for various liver disorders without a scientific rationale. This is the first experimental evaluation of the anti-hepatitis B virus (HBV) potential of the total ethanolic and sequential organic extracts of 60 candidate medicinal plants. The extracts were tested for toxicity on HepG2.2.15 cells and cytotoxicity concentration (C...

Objective: In this study, we evaluated anti-inflammatory activity of leaves of Fumaria parviflora (F. parviflora) and underlying mechanisms by using in vivo models of inflammation.Material and Methods: Albino Wistar rats of either sex weighing 150 - 200 g were used. Soxhlet ethanol and aqueous extracts of leaves of F. parviflora (EFP and AFP) were prepared. The anti-inflammatory activity was st...

In the current study, 33 isoquinoline alkaloids belonging to protopine-, benzylisoquinoline-, benzophenanthridine-, spirobenzylisoquinoline-, phthalideisoquinoline-, aporphine-, protoberberine-, cularine-, and isoquinolone-types as well as 7 derivatives of them obtained from some Fumaria and Corydalis species growing in Turkey have been evaluated for their in vitro antiviral and antimicrobial a...

BACKGROUND There is growing concern that occupational, environmental and lifestyle factors adversely affect male reproductive health. Fumaria parviflora Lam. is being used traditionally in Persian folk medicine to cure various ailments and has been supposed to have fertility-enhancing properties. OBJECTIVE A dose-response study was designed to assess effects of F. parviflora ethanolic leaves ...

The standardized 50% ethanolic extract of Fumaria indica (FI) containing 0.45% fumaric acid and 0.35% dimethyl fumarate w/w, was used in this study. Five groups of rats and mice of either sex, each group comprising of six animals, were used (i.e. control, respective standard drug, and 100 mg/kg, 200 mg/kg and 400 mg/kg doses of FI, p.o.). Potentiation of pentobarbital induced sleeping time, loc...

Objective: To evaluate the anti-stress activity of standardized extract of Fumaria indica (FI) through validated behavioral models of rodents followed by estimation of biochemical changes associated with chronic stress. Methods: Fifty percent ethanolic extract of FI used in this study was standardized on its contents of fumaric acid and its conjugates (0.45% and 0.35% respectively). Stressed Ch...

Plant-derived natural products are known to have cancer chemo-preventive and chemo-therapeutic properties. Plant extracts or their active constituents are used as folk medicine in traditional therapies by 80% of the world population. The aim of the present study was to determine the anti-proliferative potential of Fumaria vaillantii extracts on three different cancer cell lines including malign...