Heme, a major functional form of iron in the cell, is synthesized in the mitochondria by ferrochelatase inserting ferrous iron into protoporphyrin IX. Heme deficiency was induced with N-methylprotoporphyrin IX, a selective inhibitor of ferrochelatase, in two human brain cell lines, SHSY5Y (neuroblastoma) and U373 (astrocytoma), as well as in rat primary hippocampal neurons. Heme deficiency in b...

We evaluated the usefulness of RET-Y and RBC-Y in distinguishing functional iron deficiency from iron-deficiency anaemia (IDA) in patients with anaemia of inflammation (AI). Sixty healthy blood donors constituted the control group. We studied RET-Y and RBC-Y in 115 patients with hypochromic/microcytic anaemia. Of these 42 patients had uncomplicated IDA and 73 had AI. The AI patients were furthe...

BACKGROUND In the early weeks of life, very low birth weight (VLBW) infants experience intense laboratory blood sampling leading to clinically significant anemia and the need for red blood cell transfusion. Although controversial, treatment with recombinant human erythropoietin (EPO) and iron has been recommended to stimulate erythropoiesis; optimal dosing of EPO and iron is still uncertain. ...

background: iron deficiency is the most common single-nutrient deficiency disease in the world and is a major concern for about 15% of the world population.  it has been shown that iron deficiency may affect thyroid hormones.   objective: to determine thyroid hormone status in iron deficient adolescent girls.   methods: a cross-sectional study was carried out in lar province and its’ vicinity i...

Peanut/maize intercropping is a sustainable and effective agroecosystem to alleviate iron-deficiency chlorosis. Using suppression subtractive hybridization from the roots of intercropped and monocropped peanut which show different iron nutrition levels, a peanut gene, AhNRAMP1, which belongs to divalent metal transporters of the natural resistance-associated macrophage protein (NRAMP) gene fami...

This clinical report covers diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants (both breastfed and formula fed) and toddlers from birth through 3 years of age. Results of recent basic research support the concerns that iron-deficiency anemia and iron deficiency without anemia during infancy and childhood can have long-lasting detrimental effects on neurodevelopmen...

Background Endemic goiter is present in most parts of Iran. Iron deficiency adversely affects the physiology of thyroid. The initial steps of thyroid hormone synthesis are catalyzed by thyroperoxidases and are dependent on iron. In many developing countries, children are at high risk of both goiter and iron deficiency anemia. In addition, iron deficiency may alter central nervous system contro...

how to cite this article: ghasemi f, valizadeh f, taee n. iron-deficiency anemia in children with febrile seizure: a case-control study. iran j child neurol. 2014 spring 8(2):38-44. objective considering the recurrence of febrile seizure and costs for families, many studies have attempted to identify its risk factors. some recent studies have reported that anemia is more common in children with...

background: ( h.pylori ) infection is a common bacterial infection in humans. approximately half of the helicobacter pylori people throughout the world are infected by this gastric microbial pathogen. the outcome of h.pylori infection varies from gastritis to peptic ulcers, duodenal ulcers and gastric malignancies. this study aims to estimate the prevalence of h.pylori infection and iron defici...