rRNA genes are attractive targets for developing PCR assays targeting human fungal pathogens. Most studies have focused on the 18S rRNA gene, internal transcribed spacers, and the 5' end of the 28S rRNA gene. An approximately 2,900-bp region of the 28S rRNA gene remains largely unexplored because sequences of many medically relevant fungi are either unavailable or undefined in genomic databases...

In the framework of collection and identification of fungi of Zagros mountains (W and SW Iran), specimens of agaric fungi with subterraneandevelopment were collected from oak forests in Chaharmahal-va-Bakhtiari province. Native people of Dopolan and Rahimabad used hypogeous fruit-bodies of fungus as edible fungi. Excavation was done and fungal samples were found at 15–30 cm soil depth, near Oak...

Protein biosynthesis in Pisolithus Eucalyptus grandis ectomycorrhiza was related to the stage of ectomycorrhizal development using two-dimensional polyacrylamide gel electrophoresis of proteins labelled by in vivo incorporation of 35S radiolabelled amino acids. Nineteen-day-old seedlings were radiolabelled and the primary root was divided into I-cm segments. With increasing distance from the ti...

This study had the aims of evaluating the antimicrobial characteristics of Stomoxys calcitrans (Diptera: Muscidae) larvae against the fungal isolates CG138, CG228 and ESALQ986 of Beauveria bassiana sensu lato (Balsamo-Crivelli) Vuillemin, 1912 (Hypocreales: Cordycipitaceae). S. calcitrans eggs, larvae and pupae were exposed to these same isolates. Statistical analysis showed that the immature s...

Chitin is an essential structural component of the fungal cell wall. Chitinases are thought to be important for fungal cell wall remodelling, and inhibition of these enzymes has been proposed as a potential strategy for development of novel anti-fungals. The fungal pathogen Aspergillus fumigatus possesses two distinct multi-gene chitinase families. Here we explore acetazolamide as a chemical sc...

Arbuscular mycorrhiza (AM) symbioses contribute to global carbon cycles as plant hosts divert up to 20% of photosynthate to the obligate biotrophic fungi. Previous studies suggested carbohydrates as the only form of carbon transferred to the fungi. However, de novo fatty acid (FA) synthesis has not been observed in AM fungi in absence of the plant. In a forward genetic approach, we identified t...

Several five membered ring systems, e.g., triazole, oxadiazole dithiazole and thiadiazole with three heteroatoms at symmetrical or asymmetrical positions have been studied because of their interesting pharmacological properties. In this article our emphasis is on synthetic development and pharmacological activity of the triazole moiety which exhibit a broad spectrum of pharmacological activity ...

There is now a sufficient number of filamentous fungal genomes in the public databases to warrant at least initial comparisons with animal and plant genomes. Our interest lies in the control of multicellular morphogenesis, which is a feature of filamentous ascomycetes and basidiomycetes. Search of a representative collection of filamentous fungal genomes with gene sequences generally considered...

Cancer patients, especially stem cell transplantation recipients and patients with leukemia, constitute a high-risk group for the development of life-threatening systemic fungal infections. Candidiasis represents the most commonly reported fungal infection in cancer patients. Candidemia alone is associated with a mortality rate above 50% in this patient population. Even more challenging than th...

Asthma is frequently caused and/or exacerbated by sensitization to fungal allergens, which are ubiquitous in many indoor and outdoor environments. Severe asthma with fungal sensitization is characterized by airway hyperresponsiveness and bronchial constriction in response to an inhaled allergen that is worsened by environmental exposure to airborne fungi and which leads to a disease course that...