GOALS We aim to characterize the fungal microbiota in the intestinal mucosa and feces in patients with Crohn's disease (CD). BACKGROUND Fungi represent a diverse microbial community in the human intestine and might play a role in the pathogenesis of CD; however, little is known about the structure and composition of the fungal microbiota especially adhering to the intestinal mucosa in CD pati...

OBJECTIVE We report two extremely rare cases of isolated sphenoid 'fungal ball' in conjunction with vision loss. METHOD Case reports and a literature review concerning diagnosis and management of isolated sphenoid fungal ball in conjunction with vision loss. RESULTS A mycetoma or fungal ball resulting from isolated sphenoid fungal sinusitis is a rare disease. It is frequently difficult to d...

OBJECTIVE To analyse 15 cases of invasive fungal infection and mortality parameters in the largest series in the last 35 yrs of patients with systemic lupus erythematosus (SLE) at a single medical centre. METHODS Fifteen patients with SLE and invasive fungal infections were retrospectively enrolled. Clinical and laboratory data, fungal species and infected sites, corticosteroid and immunosupp...

Fungal diseases have become increasingly important in the past few years. Because few fungi are professional pathogens, fungal pathogenic mechanisms tend to be highly complex, arising in large part from adaptations of preexisting characteristics of the organisms' nonparasitic lifestyles. In the past few years, genetic approaches have elucidated many fungal virulence factors, and increasing know...

Invasive fungal infections are a leading cause of mortality among immunocompromised individuals. Treatment is notoriously difficult with the limited armamentarium of antifungal drugs, whose efficacy is compromised by host toxicity, a limited activity spectrum, or the emergence of drug resistance. We previously established that the molecular chaperone Hsp90 enables the emergence and maintenance ...

Fungi are relatively rare causes of life-threatening systemic disease in immunologically intact mammals despite being frequent pathogens in insects, amphibians, and plants. Given that virulence is a complex trait, the capacity of certain soil fungi to infect, persist, and cause disease in animals despite no apparent requirement for animal hosts in replication or survival presents a paradox. In ...

introduction cryptococcosis is an opportunistic fungal infection mostly in immunocompromised patients. here we present the immunocompetent case with crypotoccosis. case presentation a 60-year-old man without any history of immunodeficiency or major risk factor of fungal infection, referred to the emergency department with systemic symptoms and low back pain. the patient’s condition gradually de...

10.2217/14750708.4.2.125 © 2 Invasive fungal infections continue to be associated with high rates of morbidity and mortality, primarily in the immunocompromised hosts. Candida and Aspergillus are the most common causes of invasive fungal disease; however, other fungi can also cause disease in humans. Current therapeutic options for the management of invasive fungal infections include the polyen...