Penelitian yang dilakukan untuk mengembangkan modul pembelajaran dengan metode eksperimen dikaitkan dalam kehidupan sehari-hari menggunakan pendekatan Contextual Teaching and Learning (CTL). Tujuan penelitian ini adalah ikatan kimia berbasis (CTL) melalui dan menganalisis kualitas berdasarkan penilaian ahli materi, media, pendidik SMA/MA (reviewer) serta respon peserta didik terhadap kimia. Mod...

Background Exhaustion of CD8 + tumor-infiltrating lymphocytes (TILs), characterized by the overexpression immune checkpoints (IC), is a major impediment to anti-tumor immunity. However, exhaustion status TILs in angioimmunoblastic T cell lymphoma (AITL) remains unclear. Therefore, we aimed elucidate AITL and its influence on prognosis. Methods The correlation between IC expression was analyzed ...

Adoptive T cell therapy has been successfully used for treatment of viral and malignant diseases. However, little is known about the fate and trafficking of transferred Ag-specific T cells. Using the tetramer (TM) technology which allows for detection and quantification of Ag-specific CTL, we assessed the frequency of circulating Melan-A-specific CTL in advanced melanoma patients during adoptiv...

The finding that class I major histocompatibility complex (MHC)-restricted cytotoxic T lymphocytes (CTL) recognize peptide antigens (epitopes) bound to class I MHC molecules has accelerated efforts to identify CTL-defined tumor peptides for the development of peptide-based cancer immunotherapy. The Meth A sarcoma is probably one of the best studied of all murine tumors. It is extremely lethal u...

H-2 antigens encoded by the K and the D end of the major histocompatibility complex (MHC) t are the primary target structures for alloreactive cytolytic T lymphocytes (CTL) (1-3). However, little is known about the repertoire of H-2specific CTL and about which parts and epitopes of the H-2 antigens are recognized by CTL. Recently (4) we were able to identify with a panel of monoclonal antibodie...

Five distinct cytotoxic T-lymphocyte (CTL) recognition sites were identified in the simian virus 40 (SV40) T antigen by using H-2b cells that express the truncated T antigen or antigens carrying internal deletions of various sizes. Four of the CTL recognition determinants, designated sites I, II, III, and V, are H-2Db restricted, while site IV is H-2Kb restricted. The boundaries of CTL recognit...

The paper studies the expressivity, relative succinctness and complexity of satisfiability for hybrid extensions of the branching-time logics CTL and CTL by variables. Previous complexity results show that only fragments with one variable do have elementary complexity. It is shown that HCTL and HCTL, the hybrid extensions with one variable of CTL and CTL, respectively, are expressively equivale...

This study was designed to determine the role of CD25(+)CD4(+) regulatory T (Tr) cells in CTL maturation and effector functions using a murine CTL line and in vitro MLC. Tr cells inhibited CTL functional maturation, but had no effect on CTL effector functions. In CD4(+) responder T cell-depleted MLC supplemented with IL-2, Tr cells suppressed mature CTL generation only when added within the fir...

Brain-inspired neuromorphic computing has drawn significant attraction as a promising technology beyond von Neumann architecture by using the parallel structure of synapses and neurons. Various artificial synapse configurations materials have been proposed to emulate synaptic behaviors for human brain functions such memorizing, learning, visual processing. Especially, memory type indium-gallium...

Human cytomegalovirus (HCMV)-specific CD8(+) cytotoxic T lymphocytes (CTL) appear to play an important role in the control of virus replication and in protection against HCMV-related disease. We have previously reported high frequencies of memory CTL precursors (CTLp) specific to the HCMV tegument protein pp65 in the peripheral blood of healthy virus carriers. In some individuals, the CTL respo...