نتایج جستجو برای: g in exon 2

تعداد نتایج: 17477484  

Journal: :Pharmacological reports : PR 2012
Anna Grzywacz Andrzej Jasiewicz Iwona Małecka Aleksandra Suchanecka Elżbieta Grochans Beata Karakiewicz Agnieszka Samochowiec Przemysław Bieńkowski Jerzy Samochowiec

BACKGROUND We investigated the relationship between withdrawal syndrome symptoms and dopamine receptor 2 DRD2 gene polymorphisms-141 C I/D (rs1799732) exon 8 G/A (rs6276) and ANKK1 (Ankyrin Repeat and Kinase Domain Containing 1) gene polymorphism Taq1A (rs1800497). MATERIAL A total number of 213 patients who met the ICD 10 criteria for given phenotypes were enrolled in the study. Those phenot...

Journal: :DNA and cell biology 2010
Raju K Mandal Ruchika Gangwar Anil Mandhani Rama Devi Mittal

Interindividual variation in prostate cancer (PCa) susceptibility may be modulated in part through genetic polymorphisms in the DNA repair genes, especially the genes involved in the base excision repair and nucleotide excision repair pathway. Two of the common single-nucleotide polymorphisms X-ray repair cross-complementing group 1 (XRCC1) and Xeroderma pigmentosum group D (XPD) genes in PCa, ...

Journal: :The Journal of clinical endocrinology and metabolism 2000
O Chabre S Portrat-Doyen P Chaffanjon J Vivier P Liakos F Labat-Moleur E Chambaz Y Morel G Defaye

We present an in vivo and in vitro study of congenital adrenal hyperplasia in a patient with 11beta-hydroxylase deficiency. Sequencing of the CYP11B1 gene showed two new base substitutions, a conservative 954 G-->C transversion at the last base of exon 5 (T318T), and a IVS8 + 4A-->G transition in intron 8. In addition, two polymorphisms were found in exons 1 and 2. The genetically female patien...

Journal: :Neurobiology of disease 2008
Tracey D Graves Paola Imbrici Esther E Kors Gisela M Terwindt Louise H Eunson Rune R Frants Joost Haan Michel D Ferrari Peter J Goadsby Michael G Hanna Arn M J M van den Maagdenberg Dimitri M Kullmann

Premature stop codons in CACNA1A, which encodes the alpha(1A) subunit of neuronal P/Q-type (Ca(V)2.1) Ca(2+) channels, cause episodic ataxia type 2 (EA2). CACNA1A undergoes extensive alternative splicing, which contributes to the pharmacological and kinetic heterogeneity of Ca(V)2.1-mediated Ca(2+) currents. We identified three novel heterozygous stop codon mutations associated with EA2 in an a...

آذر فام, پروین, حسینپور فیضی, محمد‌علی, خانی, حوریه, منتظری, وحید, پولادی, ناصر, چاپارزاده, نادر,

Background and Objectives: Breast cancer (BC) is the most common invasive malignancy affecting women worldwide. The tumor-suppressor P53 gene (P53) is frequently mutated in breast tumors. To use P53 as a target for therapy, it is important to accurately assess p53 mutation status in tumor samples. Materials and Methods: A total of 102 tumor samples were collected from breast cancer patients ref...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Heather L Wiegand Shihua Lu Bryan R Cullen

Intron-containing genes are generally expressed more effectively in human cells than are intronless versions of the same gene. We have asked whether this effect is due directly to splicing or instead reflects the action of components of the exon junction complex (EJC) that is assembled at splice junctions after splicing is completed. Here, we show that intron removal does not enhance gene expre...

Journal: :Cell 2010
Dariel Ashton-Beaucage Christian M. Udell Hugo Lavoie Caroline Baril Martin Lefrançois Pierre Chagnon Patrick Gendron Olivier Caron-Lizotte Éric Bonneil Pierre Thibault Marc Therrien

Signaling pathways are controlled by a vast array of posttranslational mechanisms. By contrast, little is known regarding the mechanisms that regulate the expression of their core components. We conducted an RNAi screen in Drosophila for factors modulating RAS/MAPK signaling and identified the Exon Junction Complex (EJC) as a key element of this pathway. The EJC binds the exon-exon junctions of...

حسان منش, حسنا, شیخ‌الاسلامی, سارا, ظریف یگانه, مرجان, هدایتی, مهدی, کبیری, سمیرا,

Background: Thyroid carcinoma is the most common endocrine malignancy. Medullary thyroid carcinoma (MTC) approximately accounts for 5-10% of all thyroid carcinoma. Nowadays, it is obviously, the mutations in REarranged during transfection (RET) proto-oncogene, especially, mutations in exons 10, 11 and 16 are associated with MTC pathogenesis and occurrence. Thus, early diagnosis of MTC by mutati...

Journal: :iranian journal of child neurology 0
mohammad barzegar 1. pediatric health research center, tabriz university of medical sciences, tabriz, iran. 2. division of pediatric neurology, tabriz children’s hospital, tabriz university of medical sciences, tabriz, iran parinaz habibi 1. pediatric health research center, tabriz university of medical sciences, tabriz, iran. mortaza mortaza bonyady 3. center of excellence for biodiversity, department of molecular medical genetics, faculty of natural sciences university of tabriz, tabriz, iran vahideh topchizadeh 4. physical medicine & rehabilitation research center, tabriz university of medical sciences, tabriz, iran shadi shiva* 1. pediatric health research center, tabriz university of medical sciences, tabriz, iran. 2. division of pediatric neurology, tabriz children’s hospital, tabriz university of medical sciences, tabriz, iran

how to cite this article: barzegar m, habibi p, bonyady m, topchizadeh v, shiva sh. exon deletion pattern in duchene muscular dystrophy in north west of iran. iran j child neurol. 2015 winter; 9(1): 42-48. abstract objective duchene and becker muscular dystrophy (dmd/ bmd) are x-linked disorders that both are the result of heterogeneous mutations in the dystrophin gene. the frequency and distri...

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