Changes in epithelial tight junction protein expression and apoptosis increase epithelial permeability in inflammatory bowel diseases. The effect of the probiotic mixture VSL#3 on the epithelial barrier was studied in dextran sodium sulfate (DSS)-induced colitis in mice. Acute colitis was induced in BALB/c mice (3.5% DSS for 7 days). Mice were treated with either 15 mg VSL#3 or placebo via gast...

The protozoan parasite Toxoplasma gondii actively penetrates its host cell by squeezing through a moving junction that forms between the host cell plasma membrane and the parasite. During invasion, this junction selectively controls internalization of host cell plasma membrane components into the parasite-containing vacuole. Membrane lipids flowed past the junction, as shown by the presence of ...

Recessive mutations in GJA12/GJC2, the gene that encodes the gap junction protein connexin47 (Cx47), cause Pelizaeus-Merzbacher-like disease (PMLD), an early onset dysmyelinating disorder of the CNS, characterized by nystagmus, psychomotor delay, progressive spasticity and cerebellar signs. Here we describe three patients from one family with a novel recessively inherited mutation, 99C>G (predi...

Spermatogenesis is a highly complicated process in which functional spermatozoa (haploid, 1n) are generated from primitive mitotic spermatogonia (diploid, 2n). This process involves the differentiation and transformation of several types of germ cells as spermatocytes and spermatids undergo meiosis and differentiation. Due to its sophistication and complexity, testis possesses intrinsic mechani...

We report the energetics of association in polymeric gels with two types of junction points: crystalline hydrophobic junctions and polymer-nanoparticle junctions. Time-temperature superposition (TTS) of small-amplitude oscillatory rheological measurements was used to probe crystalline poly(L-lactide) (PLLA)-based gels with and without added laponite nanoparticles. For associative polymer gels, ...

This paper proposes different algorithms to tackle the Generalized Train Unit Shunting Problem (G-TUSP). is pre-operational problem of managing rolling stock in a station, between arrivals and departures. It includes four sub-problems: Matching Problem, Track Assignment Routing Maintenance Problem. In our algorithms, we consider combinations for integrated or sequential solutions these sub-prob...

The helical junction region of a -1 frameshift stimulating hairpin-type mRNA pseudoknot from sugarcane yellow leaf virus (ScYLV) is characterized by a novel C27.(G7-C14) loop 2-stem 1 minor groove base triple, which is stacked on a C8+.(G12-C28) loop 1-stem 2 major groove base triple. Substitution of C27 with adenosine reduces frameshifting efficiency to a level just twofold above the slip-site...

Abstract Vertical structures exhibit flexibility than ordinary and also they show sensitivity in earthquake excitation. As per the safety standards of construction, are built with simple uniform configurations. Focusing on aesthetic view these vertical structures, discontinuity stiffness occurs there by resulting soft storey. this feature is highly undesirable buildings especially seismic activ...

Chronic Haloperidol or Fluphenazine: Effects on Dopamine Metabolism in Brain, Cerebrospinal Fluid and Plasma of Cercopithecus Aethiops (Vervet Monkey). N. G. BACOPOULOS, D. E. REDMOND, J. BAULU AND R. H. Rom 1 Possible Mechanisms of Reduction of Plasma Luteinizing Hormone by EthanoL ROBERT E. CHAPIN, GEORGE R. BREESE AND ROBERT A. MUELLER 6 Localization and Quantitation of Lithium in Rat Tissue...

Vehicular Ad-Hoc Networks (VANETs) is a novel technology that has recently emerged and due to its swift changing topology and high mobility nature, it has become problematic to design an efficient routing protocol in VANETs’ amongst both moving and stationary units. Also, the existing routing algorithms are not very effective to satisfy all requirements of VANETs. This paper explores the need o...