background: the aim of this study was to investigate the efficacy and safety of metronomic capecitabine chemotherapy in pretreated elderly patients with advanced gastric carsonoma. patients and methods: eligible patients were treated with capecitabine at a fixed dose of 1000mg daily until disease progression or toxicity. endpoints were overall response rate, safety, progression-free survival an...

in this study the effect of nitric oxide synthesis inhibition on stress-induced gastric damage was evaluated in bile duel ligated, sham operated and unoperated rats. animals were injected intraperitoneally with ng-nitro-l-arginine methylester (l-name), 40 mglkg, l-argininc, 200 mg/kg or saline, 30 min before water-immersion stress. one hour after water immersion, the animals were killed and the...

abstract bowel obstruction is a known complication after bariatric surgery especially roux-en-y gastric bypass. the known etiologies include internal hernia, jejunojejunostomy stricture, ileus, intussusceptions, superior mesenteric artery syndrome, incarcerated port site hernia, and adhesions. blood clot is a rare cause of small intestinal obstruction after laparoscopic roux-en-y gastric bypass...

objective: helicobacter pylori has a well-established role in the development of gastric cancer. in vitro studies reveal increased proliferation of the gastric mucosa in the presence of h. pylori infection. it has been also shown that production of some cytokines, such as interleukin-1 beta (il-1b) is increased in h. pylori infection. in addition, il-1b increases proliferation of gastric epithe...

background & aim: homalium letestui pellegr (flacourtiaceae) used traditionally by the ibibios of southern nigeria to treat stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer properties.  experimental: the effects of ethanol stem extract of h. letestui (200 – 600 mg/kg) and fractions (aqueous and dichloromethane, 400 mg/kg) on experimentally induced ulcer wer...

the role of helicobacter pylori in development of gastric cancer

background: it is presumed that gastric cancer has several etiologies. first-degree relatives of patients with gastric cancer are suggested to be at higher risk compared to others. this is the first study aimed at estimating this risk, using meta-analysis of case-control studies. materials and methods: all records prior to february 2008 in pubmed and embase were searched for case-control studie...