OBJECTIVE Regarding the interaction of Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs), we cannot accept unanimous conclusions in inducing gastric ulcer. We therefore evaluated the role of Helicobacter pylori and NSAIDs in inducing gastric ulcer. METHODS Dyspeptic patients receiving NSAIDs underwent endoscopic examination. Gastric ulcer formation and H. pylori status we...

INTRODUCTION Recent epidemiological evidence supports a strong relationship between Helicobacter pylori infection and gastric cancer [1-11]. The relative risk for cancer with an infection of five years and over is in the region of three to six (Table 1). The identification of almost universal coexistence of H. pylori related antral gastritis in patients with duodenal ulcer disease [12, 13] and ...

The ABO blood group and ABH secretor status have been determined for 368 patients with a duodenal ulcer, 202 patients with a gastric ulcer, 83 patients with a stomal ulcer, 105 patients with gastric cancer, 102 patients with diabetes mellitus, and a control group of 610 subjects consisting of healthy persons and of patients with other conditions attending the same hospital. The results have bee...

BACKGROUND The pathophysiological mechanisms in non-ulcer dyspepsia are incompletely understood. AIMS To compare gastric motor and sensory functions in Helicobacter pylori positive or negative patients with non-ulcer dyspepsia. PATIENTS Seventeen patients with non-ulcer dyspepsia and 16 asymptomatic controls. METHODS The following were evaluated: gastrointestinal symptoms; gastric emptyin...

Transcription factor Nrf2 regulates the expression of detoxifying and antioxidant genes. Three promoter polymorphisms of this gene have been identified. We attempted to clarify the association of these polymorphisms with the development of peptic ulcer diseases. The study was performed with 384 stocked DNAs obtained from subjects with no evidence of gastric malignancy. In all 384 DNAs, 77 and 4...

INTRODUCTION Helicobacter pylori is one of the main causes of gastroduodenal diseases, such as chronic gastritis and peptic ulcer. It has been shown that eosinophils increase in the stomach in H. pylori infection. Eosinophilic cationic protein (ECP) is a cytotoxic molecule secreted by the activated eosinophils. However, there are no sufficient data about the role of ECP in H. pylori infection a...

The formation of new blood vessels seen in conditions commonly associated with Helicobacter pylori (H. pylori) infection, including gastritis, peptic ulcer, and gastric carcinoma, prompts consideration of a potential relationship between mucosal colonization by this organism and the angiogenic process. H. pylori directly or indirectly damages endothelial cells, which induces a number of changes...

Peptic ulcer is a common disorder of the stomach and duodenum. Herbs and medicinal plants are considered to be a potential source to combat various diseases including gastric ulcer. The present study was conducted to evaluate the gastro protective effects of Echinacea extract, Green tea extract and Boswellia extract on a pyloric ligation-induced gastric ulcer. Six groups of rats were intraperit...

The purpose of this study was to investipte the effects of metoclopramide on some gastrointestinal disorders. The author reports the results of a longitudinal study (since 1979 for 10 yrs) on 3700 patients with gastroesophageal reflux, heartburn, gastric peptic ulcer, gastritis, duodenitis, duodenal peptic ulcer and constipation due to decreas.ing intestinal peristaltism. The patients were 14-7...