The effect of conformational changes in the gate arm of a three-terminal device is investigated. In the ground state, the gate (triphenyl) arm is nonplanar, where the middle phenyl ring is approximately 30° out-of-plane relative to other two rings. At this geometry, the calculated tunnel current (Id) as a function of external bias (Vds) across the two D−A substituted arms exhibits a typical ins...

The bacterial mechanosensitive channel MscL gates in response to membrane tension as a result of mechanical force transmitted directly to the channel from the lipid bilayer. MscL represents an excellent model system to study the basic biophysical principles of mechanosensory transduction. However, understanding of the essential structural components that transduce bilayer tension into channel g...

An improved version of motion-adapted gating useful in MR imaging is presented. Compared to other gating approaches, this advances method shows an improved ability to suppress motion artefacts at a reduced scan time. It is based on a k-space dependent weighting function and a realtime system feedback. During MR data acquisition patient motion ismonitored and only those profiles are accepted who...

vvd, a gene regulating light responses in Neurospora, encodes a novel member of the PAS/LOV protein superfamily. VVD defines a circadian clock-associated autoregulatory feedback loop that influences light resetting, modulates circadian gating of input by connecting output and input, and regulates light adaptation. Rapidly light induced, vvd is an early repressor of light-regulated processes. Fu...

Foundries represent an important sector of the manufacturing industry and these foundry industries in developing countries suffer from poor quality and productivity due to number of process parameters involved in the casting process. Even in a completely controlled process, defects in casting are observed and hence casting process is also known as process of uncertainty which challenges explana...

In this research, the effect of friction between the liquid metal and the sand mould wall and the effect of passage of liquid through a vertical bend and through a ceramic filter on the fluid flow and the melt velocity has been studied by measuring the velocity of the melt and direct observation of the liquid flow through the different parts of a naturally-pressurized running system. The fricti...

Power gating is a technique for low power design in which whole sections of the chip are powered off when they are not needed, and powered back on when they are. Functional correctness of power gating is usually checked as part of system-level verification, where the most widely used technique is simulation using pseudo-random stimuli. We propose instead to perform a sequential equivalence chec...

Voltage-gated sodium channels activate in response to depolarization, but it is unknown whether the voltage-sensing arginines in their S4 segments pivot across the lipid bilayer as voltage sensor paddles or move through the protein in a gating pore. Here we report that mutation of pairs of arginine gating charges to glutamine induces cation permeation through a gating pore in domain II of the N...

In this paper a new neural network (NN) architecture for data driven prediction of accent labels—perceptual accents and pitch accents—for speech synthesis is presented. Within the proposed NN architecture, gating clusters are applied in a time delay (TD) framework. Gating clusters enable the dynamic adaptation of a network structure depending on the actual input to the NN. In the proposed TD fr...