OBJECTIVE The aim of this study was to compare the estimated glomerular filtration rate (GFR) using the Cockcroft-Gault and the 4-, 5-, and 6-variable Modification of Diet in Renal Disease (MDRD) formulas for digoxin dose adjustment. METHODS Steady-state serum digoxin concentrations were determined in 100 patients with heart failure and normal to severely impaired renal function. Total cleara...

The $\sim$4 km diameter main belt asteroid 6478 Gault has ejected dust intermittently since at least 2013. character of the emission, including its episodic nature and low speed particles ($V \sim $ 0.15 m s$^{-1}$), is most consistent with mass loss from a body rotating near rotational breakup. Owing to contamination nucleus signal, this conclusion not yet been confirmed. To test idea, we have...

BACKGROUND & AIMS There is a close relationship between chronic hepatitis B virus infection and chronic renal disease. We analyzed changes in renal function using different markers of glomerular filtration rate (GFR) in multiple studies of telbivudine treatment of patients with chronic hepatitis B virus infection. METHODS We used serum creatinine-based equations (ie, Cockcroft-Gault, Modifica...

BACKGROUND We estimated the heritability of three measures of glomerular filtration rate (GFR) in hypertensive families of African descent in the Seychelles (Indian Ocean). METHODS Families with at least two hypertensive siblings and an average of two normotensive siblings were identified through a national hypertension register. Using the ASSOC program in SAGE (Statistical Analysis in Geneti...

We investigated whether renal function and microalbuminuria are independent predictors and whether any interaction exists between them, regarding future cardiovascular disease in hypertensive patients (n=10 881) followed for 4.5 years. The primary end points (PEs) were fatal and nonfatal myocardial infarction and stroke and other cardiovascular deaths. Creatinine and glomerular filtration rate ...

BACKGROUND Rapid estimation of the renal function is widely used in clinical practice. METHODS The validity of rapid estimation of renal function as well as long-term changes in renal function from the Cockcroft-Gault formula for estimation of creatinine clearance or from serum creatinine measurements was evaluated against the 51Cr-EDTA plasma clearance technique in 36 type 2 diabetic patient...

We investigated whether renal function and microalbuminuria are independent predictors and whether any interaction exists between them, regarding future cardiovascular disease in hypertensive patients (n 10 881) followed for 4.5 years. The primary end points (PEs) were fatal and nonfatal myocardial infarction and stroke and other cardiovascular deaths. Creatinine and glomerular filtration rate ...

BACKGROUND To study the renal function (FR) of the hypertensive patients by means of estimating equations and serum creatinine (Crp). To calculate the percentage of patients with chronic kidney disease (ERC) that present normal values of Crp. To analyze which factors collaborate in the deterioration of the FR. METHODS Descriptive cross-sectional study of patients with HTA. Crp and arterial te...

Glomerular filtration rate (GFR) is commonly assessed by measurement of endogenous creatinine clearance (Ccr). Several formulae have been described to calculate Ccr from plasma creatinine. I have evaluated the effectiveness of four formulae in 35 healthy subjects (21M and 14F, 18-34 years) and in 41 patients (24M, 17F, 20-69 years) attending a renal clinic with diminished renal function (serum ...