The mouse limb deformity (ld) phenotype is characterized by developmental failure of distal limb structures often associated with renal anomalies. It is caused by loss of the BMP-antagonist Gremlin in the limb buds, either through mutation of Grem1, or by loss of a transcriptional global control region (GCR) located in the neighboring Fmn1 gene. In this report, we describe a new allele of ld du...

Recent clinical data have shown that enzyme replacement therapy with macrophage-targeted glucocerebrosidase (GCR) can be effective in treating type 1 Gaucher disease. Sera from 262 patients, repeatedly infused with GCR, were assessed for the presence of antibodies to this therapeutic protein. Patient serum samples obtained at 3-month intervals were assessed by enzyme-linked immunosorbent assay ...

Zusammenfassung. Hintergrund: Der korrekt angewandte Advanced Nursing Process führt nachweislich zu genaueren Pflegediagnosen und besseren Patientenergebnissen. ieser erfordert Wissen, klinische Entscheidungsfindungskompetenz eine positive Einstellung Pflegender. Frühere Guided Clinical Reasoning (GCR)-Schulungen erhöhten die Qualität des signifikant. Die Übereinstimmung der Dokumentationen mit...

Abstract On the 70th anniversary of UN Refugee Convention, this article examines concept solidarity and explains its relevance today, through lens Global Compact on Refugees (GCR). While stressing potential as well challenges for thorough implementation mechanisms established by GCR, argues that regional organizations may contribute to meeting GCR objectives. This is particularly urgent regions...

Tungsten isotope compositions of magmatic iron meteorites yield ages of differentiation that are within 72 Ma of the formation of CAIs, with the exception of IVB irons that plot to systematically less radiogenic compositions yielding erroneously old ages. Secondary neutron capture due to galactic cosmic ray (GCR) irradiation is known to lower the eW of iron meteorites, adequate correction of wh...

by iterative methods based on recycling Krylov subspaces. We propose two recycling algorithms, which are both based on the generalized conjugate residual (GCR) method. The recycling methods reuse the descent vectors computed while solving the previous linear systems Ax = bj , j = 1, 2, . . . , i − 1, such that a lot of computational work can be saved when solving the current system Ax = bi. Whe...