Retinopathy of prematurity (ROP) is a disorder of neonatal retinal vascularization. The incidence is increasing in developing countries like India in view of the rising numbers of preterm deliveries and improved neonatal care. Traditional modalities of treatment included cryotherapy and laser therapy, which were laborious and required special training. Hence, research is on way to find novel tr...

L-4 directs mouse and human B cells to produce, respectively, IgG1 and IgE or IgG4 and IgE (1-6) . Recently, we (7) and others (8) cloned and expressed another T cellderived cytokine (IL-13) . As with IL-4, IL-13 induces human B cells to switch to IgG4 and IgE production in an IL-4independent fashion (7-9, 10) . IL-13 shares many other properties with IL-4 . Like IL-4, it has growth-promoting e...

We tested the ability of recombinant human stem cell factor (SCF) to stimulate isolated marrow precursor cells to form colonies in semisolid media and to generate colony-forming cells (CFC) in liquid culture. SCF, in combination with interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), or granulocyte colony-stimulating factor (GCSF) caused CD34+ cells t o form increa...

The toxicity effects of several anticancer drugs on normal mouse bone marrow (BM) were estimated using the in vitro proliferative responsive ness (| 'I I]iIi>midine incorporation) of the treated BM cells to recombinant human granulocyte colony-stimulating factor (G-CSF) and recombinant human interleukin 2 (IL-2). From the response pattern of the treated BM cells to G-CSF and IL-2, the anticance...

BACKGROUND G6PC3 deficiency is a new neutropenic syndrome, which is characterized by severe persistent neutropenia, early onset infections and additional organ involvement, especially cardiac and urogenital malformations. CASE PRESENTATION In this report, we present the clinical details of a recently known case of severe congenital neutropenia (SCN) with G6PC3 mutation, who experienced the fi...

Granulocyte colony-stimulating factor (G-CSF) induces rapid phosphorylation of JAK kinases as well as activation of the p2lras route through interaction with its specific receptor (G-CSF-RI. The cytoplasmic membrane-proximal region of GCSF-R (amino acids 631 to 684) is necessary for proliferation induction and activation of JAW. In contrast, activation of Shc and Syp, signaling molecules implic...

OBJECTIVES To characterize granulocyte colony-stimulating factor receptor (CD114) expression in normal (n = 20), myelodysplastic (n = 34), and chronic myelogenous leukemia (CML; n = 5) bone marrow by flow cytometry. METHODS Clinical bone marrow samples were analyzed using CD33/CD114/CD34/CD117/CD45. CD114 density (mean fluorescence intensity) and cellular distribution were evaluated on early ...

Chemotherapy-induced neutropenia often occurs in our routine work and presents an obstacle for adequate (dose and continuance) treatment, which may affect patients' outcome. Granulocyte colony-stimulating factors (GCSFs) effectively prevent myelosuppression and thus improve the standard treatment. Through their application cases of chemotherapy-induced neutropenia have been reduced. Still these...

Craniospinal irradiation (CSI) is employed to reduce the risk of dissemination of primary CNS tumors through the CSF pathways and thereby improve survival. While it is the way of elective or therapeutic treatment in some patients with cranial ependymoma, primary cerebral lymphoma and germ cell tumors, it is of proven benefit in patients with medulloblastoma and other primitive neuroectodermal t...