Pancreatic ductal adenocarcinoma (PDAC) is the worst prognoses among all the malignancies. Now, gemcitabine (Gem) is the first line chemotherapeutic drug for advanced pancreatic cancer. However, Gem is usually ineffective to the PDAC because of high degree of drug resistance. Hypoxia and immune suppressive milieu are the best-described hallmarks of PDAC; therefore, we investigated the impact of...

The aberrant expression of DNA methyltransferases (DNMTs) has been considered to be associated with pancreatic carcinogenesis and progression. DNMT3a is widely involved in cell proliferation and cell cycle progression in pancreatic ductal adenocarcinoma (PDAC) cells. However, its regulation of chemosensitivity to gemcitabine (GEM) and oxaliplatin (OXA) in p53‑deficient PDAC remains unclear. In ...

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers due to a late diagnosis and poor response to available treatments. There is a need to identify complementary treatment strategies that will enhance the efficacy and reduce the toxicity of currently used therapeutic approaches. We investigated the ability of a known ROS inducer, piperlongumine (PL), to complement the modest ...

The aim of this study was to develop a novel multifunctional nanoparticle, which encapsulates SPION and Gemcitabine in PLGA ± PEG to form multifunctional drug delivery system. For this aim, super paramagnetic iron oxide nanoparticles (SPIONs) were simultaneously synthesized and encapsulated with Gemcitabine (Gem) in PLGA ± PEG copolymers via W/O/W double emulsification method. Optimum size and ...

Gem GTPase is a member of a protein family that includes Rad, Rem and Rem2. Although until recently precious little was known about the function of Gem, recent studies have revealed that Gem may influence cell morphology by antagonising the actions of the Rho GTPase effector protein ROCK I.

We present the results of detailed investigations of the Gas Electron Multiplier (GEM)-based photomultiplier, consisting of a solid CsI photocathode coupled to a cascade of GEM elements. The detector is "lled with non-ageing mixtures based on noble gases: Ar, Ne, Ar#Ne, Ar#Xe, Ar#CH 4 and Ar#N 2 . Very high gas gains, reaching 106, and rather fast anode pulses, of a width of 10 ns, were observe...

In this study, a liquid formulation of influenza subunit vaccine admixed with Gram-positive enhancer matrix (GEM) particles as adjuvant was delivered to upper and lower parts of intestinal tract. The aim was to determine the most effective immunization site in the intestines. Mice were vaccinated with a liquid formulation of GEM and influenza subunit vaccine orally and rectally. The oral admini...

The global financial crisis hastened the development of the Shenzhen GEM is a venture capital a key link in the chain, force the development of SME financing difficulty in resolving the issue. In view of the characteristics and specific risks of Growth Enterprise Market (GEM), this paper measures the market risk of 28 listed companies on the GEM by use of VaR techniques, and introduces VaR into...

We have operated the Gas Electron Multiplier (GEM) coupled to a CsI photocathode for the detection of single UV photons. Gains of up to 10 000 were observed with a single GEM in pure hydrocarbons in the range 40}400 Torr. Using a double-GEM structure, we have detected single photoelectrons on a strip electrode. We have studied the single-electron detection e$ciency of the GEM, a crucial paramet...

The effectiveness and efficiency of outpatient geriatric evaluation and management (GEM) was compared to usual outpatient primary care (UPC). Although GEM had no overall impact on health care utilization or cost of care for the entire study period, significant reductions were found during the sixteen- to twenty-four-month study period, suggesting a possible investment effect. In the first eight...