Background and Aims: The current paradigm of specialist physician-managed treatment of chronic hepatitis C virus infection (HCV) is inefficient in absorbing the approximately 3 million patients awaiting treatment in the United States. Task shifting-whereby specialist physicians screen patients for treatment eligibility but on-treatment monitoring is devolved to more abundant non-physician clini...

Definition 2 (Multi-message secure encryption) (Gen,Enc,Dec) is a multi-message secure encryption scheme if for all nuPPT A, for all polynomial q(·) there exists a negligible function (·) such that ∀ n ∈ N and for all pairs of sequences of messages m0,m1, . . . ,mq(n), m ′ 0,m ′ 1, . . . ,m ′ q(n) ∈ {0, 1} , A distinguishes {k ← Gen(1) : Enck(m0), . . . , Enck(mq(n))} {k ← Gen(1) : Enck(m0), . ...

BACKGROUND/AIMS Arsenic trioxide (As2O3) is a highly effective agent for treatment of acute promyelocytic leukemia (APL). However, consecutively administered As2O3 induces serious adverse cardiac effects, including long QT syndrome (LQTs) and even sudden cardiac death. Previous studies have shown that genistein (Gen) exerts anti-oxidant, anti-inflammatory, and anti-apoptotic effects. The presen...

We have demonstrated that genistein (GEN) stimulates growth of estrogen-dependent breast tumors in vivo. In this study, we evaluated whether dietary GEN can act in an additive manner with low circulating levels of 17beta-estradiol (E2). We developed an E2 delivery system using silastic implants that yield low circulating plasma E2 levels similar to those observed in postmenopausal women. We ins...

Immunotherapeutic herpes simplex virus 2 (HSV-2) vaccine efficacy depends upon the promotion of antigen-specific immune responses that inhibit reactivation or reactivated virus, thus controlling both recurrent lesions and viral shedding. In the present study, a candidate subunit vaccine, GEN-003/MM-2, was evaluated for its ability to induce a broad-spectrum immune response in mice and therapeut...

Two new genera of Riodinidae (Insecta: Lepidoptera) are described, Neoapodemia Trujano-Ortega, gen. n. (Neoapodemia nais (W. H. Edwards, 1876), comb. n., N. chisosensis Freeman, 1964, comb. n.) and Plesioarida Trujano-Ortega & García-Vázquez, gen. n. (Plesioarida palmerii palmerii (W. H. Edwards, 1870), comb. n., P. palmerii arizona (Austin, [1989]), comb. n., P. palmerii australis (Austin, [19...

Subfamily Tripetalocerinae consist of four genera distributed in Southeast Asia. Clinophaestus gen. nov. (type species: Clinophaestus robustus sp. nov.) and Tripetaloceroides gen. nov. (type species: Tripetalocera tonkinensis Gunther, 1938) are described. New tribe Clinophaestini trib. nov. (type genus: Clinophaestus gen. nov.) is established. Diagnosis and key to tribes and genera are given. A...

Background: Genetic changeability of hepatitis B virus (HBV) signifies a challenge for the sensitivity of immunologic and molecular diagnostics. Therefore, knowing the spread of HBV genotypes (GENs) and mutation has considerable impacts on treatment strategies, vaccination program, diagnosis, and prevention. The present study aimed to detect HBV GENs and mutants in HBsAg-positive patients. Meth...

B S Mahesh1, S Padmashree2, Hima John3, J Rema4 1Senior Lecturer, Department of Oral Medicine and Radiology, Vydehi Institute of Dental Sciences, Bengaluru, Karnataka, India, 2Professor and Head, Department of Oral Medicine and Radiology, Vydehi Institute of Dental Sciences, Bengaluru, Karnataka, India, 3Senior Lecturer, Department of Oral Medicine and Radiology, Annoor Dental College, Ernaulam...