Although high levels of tumor-infiltrating lymphocytes (TILs) generally correlate with good prognosis in high-grade serous ovarian cancer (HGSC) patients, little is known about the phenotype or specificity of these cells. We have recently demonstrated that TIL expressing the intra-epithelial lymphocyte marker CD103 (official name, integrin αE, ITGAE) abundantly infiltrate HGSCs, strongly correl...

Metastatic cell heterogeneity presents a significant obstacle to the development of targeted molecular and immunotherapeutics. Profiling of melanocyte differentiation antigens has revealed a nonstochastic, site-specific pattern of expression in metastases that was highest in brain, intermediate in soft tissues/lymph nodes, and lowest in visceral sites. Site-specific antigen heterogeneity, thus,...

Background One of the main causes of male infertility is defect in structure and function of sperm cells. Infertile men with oligoasthenoteratospermia (OAT) defect, have sperms with abnormalities in count, motility and morphology. Patients with immotile short tail sperm (ISTS) disorder have immotile short-tailed sperm with disorganized axonem, and a significant decrease in sperm counts. Numerou...

Pain is a useful sensation. Nociceptive pain provides warning of impending or actual tissue damage and prompts aversive or attentive actions that protect the body from harm. People who do not feel pain, due to mutation of certain ion channels (1), suffer a lifetime of otherwise avoidable injuries. The consequences of losing the ability to feel pain also are highlighted by the symptoms and clini...

haemoglobin designed for use as a “blood substitute.” Nature 1992; 356:258–60 10. Levy JH, Despotis GJ, Olson PJ, Weisinger A, Szlam F: Transgenically produced recombinant human ATIII enhances the antithrombotic effects of heparin in patients undergoing cardiac surgery. Blood 1997; 90(Suppl 1):298A 11. Levy JH, Goodnough LT, Grelich P, Parr G, Steward RW, Gratz I, Wahr J, Williams J, Comunale M...

Thanks to Pylyshyn's work in the imagery debate, theorists are now apt to be at least a bit more cautious when they launch into descriptions of depictive representation. Even if the full force of his critique is not everywhere acknowledged, more care and vigilance is exercized when broaching talk of scanning mental images, focusing on such entities, or rotating them. The very places found in me...