نتایج جستجو برای: gene tb
تعداد نتایج: 1164898 فیلتر نتایج به سال:
Tuberculosis (TB) remains one of the health problems in Nigeria and worldwide. Adenosine Deaminase acts proliferation differentiation lymphocyte, especially T lymphocyte. It also maturation monocytes transforming them to macrophage. is a significant indicator active cellular immunity. has been proposed be useful surrogate marker for TB because it can detected body fluids such as pleural, perica...
BACKGROUND. Novel rapid diagnostics for active tuberculosis (TB) are required to overcome the time delays and inadequate sensitivity of current microbiological tests that are critically dependent on sampling the site of disease. Multiparametric blood transcriptomic signatures of TB have been described as potential diagnostic tests. We sought to identify the best transcript candidates as host bi...
Pattern-recognition receptors (PRRs) play a key role in innate immunity against intracellular bacteria. NOD2 is one of the PRRs that contribute to the immune response to Mycobacterium tuberculosis infection. We sequenced coding regions of the NOD2 gene in 377 African Americans with tuberculosis (TB) disease and 187 ethnically matched control subjects. Three common nonsynonymous single-nucleotid...
Despite the discovery of the causative agent of tuberculosis (TB), Mycobacterium tuberculosis, more than 120 years ago TB remains a major worldwide health problem. Currently, the attenuated strain of M. bovis, Bacille Calmette-Güerin (BCG) is the only vaccine available against TB. Although BCG is the world's most widely used vaccine, its protective value as an anti-TB vaccine for adults in cert...
Previous studies of antibody responses to Mycobacterium tuberculosis antigens at different stages of tuberculosis (TB) and in different classes of TB patients provided evidence that the profile of antigens recognized by antibodies is altered with disease progression. M. tuberculosis is a slow-growing organism, and it takes several weeks to months for an infection to progress to clinical TB. App...
Mannose-binding lectin (MBL) is able to bind pathogens as an opsonin and plays an important role in the innate immunity. The aim of the present study was to determine the frequencies of the MBL gene variants in the Turkish population and to examine the presence of any association between MBL variants and development of tuberculosis (TB) in adults and recurrent respiratory tract infections in ch...
BACKGROUND Mannose-binding lectin (MBL) and MBL-associated serine proteases 2 (MASP-2) are important proteins in the lectin pathway of the immune system. Polymorphism of MBL and MASP-2 genes may affect the serum concentration of MBL and MASP-2. This study explores the association between MBL and MASP-2 gene polymorphism and their interactions and the susceptibility to tuberculosis (TB). METHO...
Tuberculosis (TB) is a devastating disease that affects humans and many animal species. In humans, TB is mainly caused by Mycobacterium tuberculosis, whereas most cases in cattle are caused by Mycobacterium bovis. However, M. bovis can also cause, albeit rarely, human TB. In PNAS, Wu et al. (1) report the use of novel genetic tools to demonstrate that insertion of one gene into a genomic “safe ...
BACKGROUND Besides inclusion in 1st line regimens against tuberculosis (TB), pyrazinamide (PZA) is used in 2nd line anti-TB regimens, including in the short regimen for multidrug-resistant TB (MDR-TB) patients. Guidelines and expert opinions are contradictory about inclusion of PZA in case of resistance. Moreover, drug susceptibility testing (DST) for PZA is not often applied in routine testing...
Lately, much effort has been made to find mRNA biomarkers for tuberculosis (TB) disease/infection with microarray-based approaches. In a pilot investigation, through RNA sequencing technology, we observed a prominent modulation of DOCK9, EPHA4, and NPC2 mRNA abundance in the blood of TB patients. To corroborate these findings, independent validations were performed in cohorts from different are...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید