Hans Reinke * and Gad Asher * 1 University of Düsseldorf, Medical Faculty, Institute of Clinical Chemistry and Laboratory Diagnostics, 40225 Düsseldorf, Germany. 2 IUF-Leibniz Research Institute for Environmental Medicine, 40225 Düsseldorf, Germany. 3 Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, 7610001, Israel. * Correspondence to: [email protected]...

Animal models of human diseases of the central nervous system, generalized anxiety disorder included, are essential for the study of the brain-behavior interface and obligatory for drug development; yet, these models fail to yield new insights and efficacious drugs. By increasing testing duration hundredfold and arena size tenfold, and comparing the behavior of the common animal model to that o...

Original Article COMPARING FOUR ELECTRICAL STIMULATORS WITH DIFFERENT PULSES PROPERTIES AND THEIR EFFECT ON THE DISCOMFORT AND ELICITED DORSIFLEXION Gad Alon 1*, David G. Embrey 2, Brenna A. Brandsma 3, Jeff Stonestreet 4. 1* Associate Professor, Emeritus, University of Maryland, School of Medicine, Baltimore, MD 2 Research Program Coordinator, MultiCare Good Samaritan, Puyallup, WA and Clinica...

We consider the problem of finding the spectrum of an operator taking the form of a low-rank (rank one or two) non-normal perturbation of a well-understood operator, motivated by a number of problems of applied interest which take this form. We use the fact that the system is a low-rank perturbation of a solved problem, together with a simple idea of classical differential geometry (the envelop...

BACKGROUND Anxiety symptoms are associated with elevated coronary heart disease (CHD) risk, but it is not known whether such associations extend to anxiety disorders or if they are independent of depression. We sought to determine if generalized anxiety disorder is associated with elevated CHD risk, and whether this association is independent of or interacts with major depressive disorder. ME...

This study examined associations of generalized and social anxiety with (1) age at first use of tobacco, alcohol, and marijuana and (2) interval from first use to first problem use of each substance. Participants were 503 males who comprised the youngest cohort (first assessed in the first grade) of the Pittsburgh Youth Study, a longitudinal community-based study of boys. Annual assessments of ...

BACKGROUND Nocturnal enuresis, often called bedwetting or sleep wetting, is a common problem in children after the age of five and may lead to symptoms such as infection, incontinence and frequent urination. This problem refers to a state in which children after the age of five have no control of their urine for six continuous months and it cannot be attributed to any organic factors or drug us...

the purpose of this research was to investigate the effectiveness of eclectic model based on acceptance and commitment therapy (act) and metacognitive therapy (mct) on symptoms in patient with pure generalized anxiety disorder. the research method was clinical experimentation with pre-posttest and control group. statistic community was all of the men and women patients that suffered from pure g...

ôbjective: previous studies have suggested that anxiety disorders are more prevalent among women than men. the purpose of this study was to compare the metacognitive perspective of generalized ânxiety disorder (gâd) in females with males. methods: â cross sectional study was conducted on the high school girls and boys who have been affected by gâd. the sample consisted of 100 high school studen...