The relationship between DSM-IV anxiety disorders and their clinical characteristics in mothers and anxiety in offspring was examined in 933 mother-child pairs from a longitudinal community study. Offspring of mothers with an anxiety disorder had an elevated risk of developing any anxiety disorder, compared with offspring of mothers with no anxiety disorder. Increased risk of anxiety in the off...

OBJECTIVE Few neuroimaging studies of generalized anxiety disorder have been conducted. The present study used proton magnetic resonance spectroscopy to assess concentrations of N-acetylaspartate, often considered a marker of neuronal viability, in generalized anxiety disorder patients. METHOD N-Acetylaspartate/creatine resonance ratios were measured in the left and right dorsolateral prefron...

Strategies for Assessing and Treating Comorbid Panic and Generalized Anxiety Disorder, by Kristalyn Salters-Pedneault, PhD Can Anticonvulsants Help Patients With Anxiety Disorders? by Marco Mula, MD, PhD SSRIs as Antihypertensives in Patients With Autonomic Panic Disorder, by Sean Hood, MBBS, MSc Achieving Remission in Generalized Anxiety Disorder, by Laura A. Mandos, PharmD, Jennifer A. Reinho...

Hans Reinke * and Gad Asher * 1 University of Düsseldorf, Medical Faculty, Institute of Clinical Chemistry and Laboratory Diagnostics, 40225 Düsseldorf, Germany. 2 IUF-Leibniz Research Institute for Environmental Medicine, 40225 Düsseldorf, Germany. 3 Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, 7610001, Israel. * Correspondence to: [email protected]...

Animal models of human diseases of the central nervous system, generalized anxiety disorder included, are essential for the study of the brain-behavior interface and obligatory for drug development; yet, these models fail to yield new insights and efficacious drugs. By increasing testing duration hundredfold and arena size tenfold, and comparing the behavior of the common animal model to that o...

Original Article COMPARING FOUR ELECTRICAL STIMULATORS WITH DIFFERENT PULSES PROPERTIES AND THEIR EFFECT ON THE DISCOMFORT AND ELICITED DORSIFLEXION Gad Alon 1*, David G. Embrey 2, Brenna A. Brandsma 3, Jeff Stonestreet 4. 1* Associate Professor, Emeritus, University of Maryland, School of Medicine, Baltimore, MD 2 Research Program Coordinator, MultiCare Good Samaritan, Puyallup, WA and Clinica...

We consider the problem of finding the spectrum of an operator taking the form of a low-rank (rank one or two) non-normal perturbation of a well-understood operator, motivated by a number of problems of applied interest which take this form. We use the fact that the system is a low-rank perturbation of a solved problem, together with a simple idea of classical differential geometry (the envelop...

BACKGROUND Anxiety symptoms are associated with elevated coronary heart disease (CHD) risk, but it is not known whether such associations extend to anxiety disorders or if they are independent of depression. We sought to determine if generalized anxiety disorder is associated with elevated CHD risk, and whether this association is independent of or interacts with major depressive disorder. ME...

This study examined associations of generalized and social anxiety with (1) age at first use of tobacco, alcohol, and marijuana and (2) interval from first use to first problem use of each substance. Participants were 503 males who comprised the youngest cohort (first assessed in the first grade) of the Pittsburgh Youth Study, a longitudinal community-based study of boys. Annual assessments of ...