background: essential hypertension tends to a familial mode. its pattern of inheritance is heterogeneous, but the frequencies of different mode of inheritance vary in different populations. determining of the mode of inheritance in each family is the basic information that is needed for the risk estimation in those family members. determination of pattern of inheritance in families with at leas...

The K-means method is one of the most widely used clustering methods and has been implemented in many fields of science and technology. One of the major problems of the k-means algorithm is that it may produce empty clusters depending on initial center vectors. Genetic Algorithms (GAs) are adaptive heuristic search algorithm based on the evolutionary principles of natural selection and genetics...

Genetic algorithm is a search algorithm based on the mechanics of natural selection and natural genetics. The purpose of this master thesis is to optimize/maximize de Jong’s function1 in GA using different selection schemes (like roulette wheel,random selection, besy fit/elitist fit rank selection, tournament selection). For our problem the fitness function chosen is from literature of benchmar...

We introduce a powerful and flexible MCMC algorithm for stochastic simulation. The method builds on a pseudo-marginal method originally introduced in [Genetics 164 (2003) 1139–1160], showing how algorithms which are approximations to an idealized marginal algorithm, can share the same marginal stationary distribution as the idealized method. Theoretical results are given describing the converge...

BACKGROUND Here we report specific activities of all seven naturally occurring LinA variants towards three different isomers, α, γ and δ, of a priority persistent pollutant, hexachlorocyclohexane (HCH). Sequence-structure-function differences contributing to the differences in their stereospecificity for α-, γ-, and δ-HCH and enantiospecificity for (+)- and (-)-α -HCH are also discussed. METH...

dementia is a syndrome encompassing many intellectual domains that can be broadly defined as an overall decline in intellectual function including difficulties with language, simple calculations, planning and judgment and motor skills as well as loss of memory. a genetic cause is identified in only a minority of patients, but patients and their family members are frequently concerned about the ...

protein aggregation is thought to be the pathological driving force responsible for neurodegenerative disorders such as alzheimer’s, parkinson’s, huntington’s, frontotemporal dementia, dementia with lewy bodies and prion diseases, however, it is not yet clear whether, or to what extent, the misfolded proteins are the cause of the diseases rather than the consequences. the aggregated proteins th...