The CD4 T helper cell type 1 (Th1) response is essential for the resolution of chlamydial genital infection in mice. However, not all Th1 clones are equally protective in eradicating the infection. Since oral immunization regimens produce protective immunity, we evaluated the role of the mucosa-associated homing receptor, alpha4beta7, in trafficking to the genital mucosa. Using a panel of CD4, ...

We show that genital infection with neurotropic HSV type 2 (HSV-2) induced a significant increase of the neuropeptide substance P (SP) within the genital tract of mice. SP was shown to weakly interfere with the HSV-2 replication. Furthermore, lack of SP signaling through the use of mice deficient in the SP receptor, neurokinin 1 receptor (NK1R), revealed an important role for SP in the innate d...

IgG is a major Ig subclass in mucosal secretions of the human female genital tract, where it predominates over the IgA isotype. Despite the abundance of IgG, surprisingly little is known about where and how IgG enters the lumen of the genital tract and the exact role local IgG plays in preventing sexually transmitted diseases. We demonstrate here that the neonatal Fc receptor, FcRn, is expresse...

Resolution of Chlamydia genital tract infection is delayed in the absence of MyD88. In these studies, we first used bone marrow chimeras to demonstrate a requirement for MyD88 expression by hematopoietic cells in the presence of a wild-type epithelium. Using mixed bone marrow chimeras we then determined that MyD88 expression was specifically required in the adaptive immune compartment. Furtherm...

Breast abscesses can be a complication of infectious mastitis or the first presentation breast infection, presenting as pain, erythema, and lump. Actinomycosis is rare chronic disease caused by anaerobic branched filamentous gram-positive bacteria belonging to Actinomyces genus. It usually found in human mouth, digestive tract, genital tract but also cause abscesses. affecting condition that ty...

BACKGROUND Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen causing female genital tract infection throughout the world. Reinfection with the same serovar, as well as multiple infections with different serovars, occurs in humans. Using a murine model of female C. trachomatis genital tract infection, we determined if homotypic and/or heterotypic protection against...

Cervical swabs for Chlamydia culture were collected from 638 unselected women attending a sexually transmitted diseases clinic with a fresh complaint. Chlamydia were isolated from 76 (12 per cent.) of the women. When the results were related to the patients' diagnoses, Chlamydia were present in 44 per cent. of women with gonorrhoea and in 22 per cent. of women who were contacts of men with nons...

Chlamydia trachomatis (CT) is the leading sexually transmitted bacterial infection. The continued global burden of CT infection strongly predicates the need for a vaccine to supplement current chlamydial control programs. The correlates of protection against CT are currently unknown, but they must be carefully defined to guide vaccine design. The localized nature of chlamydial infection in colu...

A most interesting fact for scientific investigations is that 5% of women are afflicted with recurrent genital candidosis (RGC) characterized by three or more genital, fungal infection episodes per a year. The data analysis is also interesting because it reveals that the most significant risk factors such as pregnancy, diabetes mellitus, long term use of antibiotics and citostatics, hormonal th...

Actinomycosis is a very rare disease caused by Actinomyces israelii, saprophytic bacterium of the oropharynx and genital tract women. Its diagnosis made difficult lack clinical radiological specificity. We report three cases patients with actinomycosis various locations, but similar management. These recall radio-clinical therapeutic aspects this infection. They underline necessity microbiologi...