The emergence of antimicrobial resistance severely threatens our ability to treat bacterial infections. While acquired resistance has received considerable attention, relatively little is known of intrinsic resistance that allows bacteria to naturally withstand antimicrobials. Gene products that confer intrinsic resistance to antimicrobial agents may be explored for alternative antimicrobial th...

conclusions our results illustrated the presence of clonal groups of highly gentamicin-resistant strains of mrsa in hospitals in tehran. the php typing method provided useful information for both clonal dissemination and determining the epidemiological links of the clonal groups of the mrsa strains. materials and methods a total of 301 s. aureus isolates were collected during january to novembe...

Strains of Pseudomonas aeruginosa resistant to either gentamicin or carbenicillin have been noted since their introduction into clinical use. During a 6-month period, twice-weekly cultures were obtained from all patients treated with either gentamicin or carbenicillin and from all patients with a positive culture for P. aeruginosa. Susceptibility testing to gentamicin and carbenicillin and pyoc...

The susceptibility of 100 strains of Neisseria gonorrhoeae to five antimicrobial agents (penicillin, streptomycin, oxytetracycline, sulphamethoxazole, and gentamicin) was examined. Three strains were resistant to each antimicrobial, fourteen exhibited resistance to three or four of the five compounds tested, and 49 were resistant to a single agent, or to pairs of the selected agents. 34 strains...

Gentamicin is a highly efficacious antibiotic against Gram-negative bacteria. However, its usefulness in treating infections is compromised by its poorly understood renal toxicity. Toxic effects are also seen in a variety of other organisms. While the yeast Saccharomyces cerevisiae is relatively insensitive to gentamicin, mutations in any one of ∼20 genes cause a dramatic decrease in resistance...

Pseudomonas aeruginosa has a notorious characteristic of resistance to most antimicrobial compounds. This characteristic was subjected to verification in the present study, whereby 50 human isolates of the organism from different pathological sources were subjected to sensitivity tests against honey from three different sources by the agar-cup diffusion method. Gentamicin, an aminoglycoside ant...

This study evaluated the activity of daptomycin combined with either gentamicin or rifampin against three methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates in vitro and one isolate in vivo against a representative strain (MRSA-572). Time-kill experiments showed that daptomycin was bactericidal against these strains at concentrations over the MIC. Daptomycin at sub-MIC concent...

OBJECTIVES Helicobacter pylori-associated infection is common in South Africa, as in other developing countries. Antibiotic resistance is recognised as a major cause of treatment failure. We studied the susceptibility and resistance patterns of H. pylori to guide empiric treatment and prevent the emergence of resistance. METHODS Two hundred H. pylori strains obtained from gastric biopsies of ...

Properties of a population of carbenicillin- and gentamicin-resistant, tobramycin-susceptible Pseudomonas aeruginosa at Veteran's Administration Hospital, Cincinnati, Ohio, have been followed during a 16-month period. As originally described, the strains were isolated from patients with urinary tract colonizations and were predominantly Parke-Davis immunotype 7. For the majority of these organi...