The proline-rich peptide (PRP-1) isolated from neurosecretory granules of the bovine neurohypophysis, produced by N.supraopticus and N.paraventricularis, has many potentially beneficial biological effects. PRP-1 been shown to have opposite effects on cell death in neurodegenerative cancer diseases. It significantly reduces staurosporine-induced apoptosis postnatal hippocampal cells, as well dox...

BACKGROUND AND PURPOSE Systemic giant cell arteritis causing cerebellar infarction due to intracranial arteritis of the anterior inferior cerebellar artery has not been previously reported. We report this infrequent occurrence and discuss the differential diagnosis. CASE DESCRIPTION An 85-year-old woman was admitted with a 2-week history of episodic ataxia, unilateral headaches, and vomiting....

â  â  background esophageal squamous cell carcinoma (escc) is usually detected in advanced stages resulting in a very poor prognosis. early diagnoâ­sis needs identification of clinically relevant precancerous lesions which could become the target of screening and early treatment. our aim was to check whether esophagitis could serve as a relevant histological precursor of escc in northern iran. ...

metastatic   tumors in the nose and paranasal sinuses are infrequent. the origin of this metastatic tumors are often renal cell carcinoma. we present one case of metastatic renal cell carcinoma   to the nose and paranasal sinuses ,4 years after initial nephrectomy and diagnosis of stage t1n0m0 clear cell carcinoma. the patient complained of nasal obstruction and recurrent epistaxis   who was tr...

background and aims. there is no report on the apoptotic impact of allium sativum l. (garlic) on the oral squamous cell carcinoma (kb); hence, this study was designed to survey the apoptotic effects of garlic fresh juice (gfj) on the kb cells. materials and methods. mtt assay (microculture tetrazolium assay) was carried out to evaluate the cytotoxicity of gfj on kb cells. furthermore, tunel (te...

introduction: metastatic lesions of the oral cavity are extremely rare, accounting for approximately 1% of all malignant oral tumors. the most common primary sources of metastatic tumors in the oral region are, from the most to the least common, the breast, lung, kidney, bone, and colon. renal cell carcinoma accounts for nearly 3% of all adult malignancies. it usually metastasizes to the lungs,...

background: although giant cell tumor (gct) is considered to be a primary benign bone tumor, its aggressive behavior makes its diagnosis and treatment, difficult and challenging. this is especially true in distal radius where gct appears to be more aggressive and difficult to control locally. we report our clinical outcome of en-block resection and reconstruction with non-vascularized fibular a...

we report occurrence of a rare case of giant cell tumor (gct), in a 28-year old woman, arising from anterior arc of right 6 th rib during pregnancy. it progressed rapidly during breast-feeding period, mimicking malignant bone tumor at delayed presentation.

this is a case report concerning a 60 years old man who lived for a short period in an endemic area of khuzestan province (neighboring province of persian gulf in iran) for approximately 20 years ago. recently he referred to the urology department of kerman university of medical sciences with hematuria and dysuria. in the sonography a polypoid mass on the bladder floor was observed. in the cyst...

Pleomorphic giant cell carcinoma of the pancreas usually has a very poor prognosis with some investigators reporting a mean post-surgical survival time of just months. This poor post-surgical prognosis has led to the reappraisal of the use of surgical resection for pleomorphic carcinoma. Rcently, this carcinoma is classified as a type of anaplastic ductal carcinoma by Japanese criteria 2002. We...