The giant protein is a short-range transcriptional repressor that refines the expression pattern of gap and pair-rule genes in the Drosophila blastoderm embryo. Short-range repressors including knirps, Krüppel, and snail utilize the CtBP cofactor for repression, but it is not known whether a functional interaction with CtBP is a general property of all short-range repressors. We studied giant r...

INTRODUCTION Giant cell tumor of the bone is a relatively uncommon tumor. It is characterized by the presence of multinucleated giant cells. The tumor is usually regarded as benign. In most patients, giant cell tumors have an indolent course, but tumors recur locally in as many as 50% of cases. Metastasis to the lungs may occur. Cooper first reported giant cell tumors in the 18th century. In 19...

Giant cell tumor, excluding its prototype in bone, is usually a benign but local aggressive neoplasm originating from tendon sheath or soft tissue. Malignant behavior is uncommon. Visceral organ involvement including urinary bladder is rare. Giant cell tumors in visceral organs usually accompany epithelial tumors and the clinical behavior of giant cell tumor in urinary bladder is similar to its...

BACKGROUND In order to assess the role of binucleate giant oocytes for generating digynic triploidy, we studied their frequency, maturation patterns and chromosomal complements at metaphase II (MII) or after fertilization. METHODS Uncleaved, giant zygotes were incubated with podophyllotoxin and vinblastine, treated with hypotonic solution and fixed by a gradual fixation method. Giant MII oocy...

Skin tags are skin-colored, asymptomatic, pedunculated lesions located at the neck, axillae or groin. It affects any age, including infants. We report a 60-year-old Iranian woman with a giant pedunculated skin tag on the left thigh for 10 years. It measured 10 cm in length and 7 cm in width, distally.

Histological responses to Meloidogyne incognita infection in Rhizobium nodules of clover, horsebean, lupine, and pea were investigated. The formation of giant cells in vascular bundles of nodules and roots, and the basal connection of the nodule, were usually associated with abnormal xylem and/or deformed xylem strands. However, giant cells did not disturb or prevent the development of nodular ...

The cellular responses induced by Meloidogyne arenaria races 1 and 2 in three soybean genotypes, susceptible CNS, resistant Jackson, and resistant PI 200538, were examined by light microscopy 20 days after inoculation. Differences in giant-cell development were greater between races than among the soybean genotypes. M. arenaria race 1 stimulated small, poorly formed giant-cells in contrast with...

conclusions coronary artery aneurysm should be a differential diagnosis in cases of mediastinal cyst and mass lesion. case presentation a 32-year-old woman presented with edema of the upper and lower limbs, palpitation, and chest pain, and was diagnosed with a giant right coronary artery aneurysm that had initially mimicked a mediastinal cyst. although computed tomography (ct) suggested a media...

mediastinal lymphangioma is primarily a benign lesion and the majority of the cases are found incidentally. these lesions account for approximately 1% of all mediastinal tumors. here we present a giant mediastinal cystic mass in a 35-year-old female who was presented with severe respiratory distress. on the plain chest radiography and ct scan, a massive left pleural effusion with large paraster...

calcifying odontogenic cyst (coc), central odontogenic fibroma (cof) and aggressive central giant cell granuloma (cgcg) are rare pathologic diseases affecting the jaws. while the co-existence of two of them is reported in the literature, existence of all three conditions in one patient is an extremely rare entity. in the present report, initial biopsy revealed fibrosarcoma, therefore mandibular...