Germline mutations in the fumarate hydratase gene (FH) predispose to multiple cutaneous and uterine leiomyoma syndrome (MCL) and MCL associated with renal cell cancer. MCL is inherited in an autosomal dominant pattern, manifesting as skin leiomyoma and uterine fibroids in affected individuals. Fumarate hydratase, a component of the tricarboxylic acid cycle, acts as a tumor suppressor gene in th...

Introduction: Leiomyoma of the uterus is the most common tumor of the female reproductive tract. While most leiomyomas on histology are usual myomas, sometimes rare variants may be encountered. Case Report: We report a case of an atypical uterine leiomyoma in a 49-year-old multipara, who presented with continuous bleeding per vaginum of one month duration and discuss the pathophysiology, salien...

Uterine fibroids (leiomyoma), the benign tumors of the uterine wall, are very common cause of morbidity in reproductive age women usually in the form of excessive vaginal bleeding, chronic pelvic pain, miscarriage and infertility. These tumors are the leading indication for hysterectomy in the United States. Uterine fibroids are about 4 times higher in blacks compared to whites and constitute a...

Unicornuate uterus is a rare congenital anomaly which occurs due to partial development of mullerian duct system. Patient with unicornuate uterus usually present with dysmenorrhoea, hematometra and endometriosis during their reproductive period. In the absence of these symptoms, proper identification and diagnosis of mullerian anomaly becomes difficult. Sometimes during laparoscopy it can mimic...

Although benign, uterine leiomyomas occur with high frequency and significant morbidity in reproductive-age women, and they present a significant health problem. Leiomyomas develop in the uterine myometrium and are sensitive to ovarian hormones, making them potential target sites for endocrine disruptors. Here we utilize cell lines derived from rat uterine leiomyomas to determine if a panel of ...

OBJECTIVE To examine urinary retention as an underreported complication of uterine leiomyoma. Reproductive-aged women with uterine leiomyoma often describe pelvic pressure and menorrhagia, however few complain of complete urinary retention. STUDY DESIGN We dis-cuss the cases of 8 women who presented to our emergency room with acute urinary retention over a 4-year period. RESULTS Patients ha...

CONTEXT Asoprisnil, a selective progesterone (P4) receptor (PR) modulator (SPRM) with mixed P4 agonist/antagonist activities, reduces uterine leiomyoma volume in a dose-dependent manner in the presence of follicular phase estrogen concentrations. The evidence from clinical studies suggests that asoprisnil may directly target the uterine leiomyomata. OBJECTIVE AND METHODS The present study eva...

OBJECTIVE The aim of this study was to investigate the anti-proliferative effect of the salinomycin in cell proliferation and apoptosis in primary cultured human uterine leiomyoma cells. METHODS Cell viability was measured by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Caspase-3 activity assay and DNA fragmentation assay were performed to determine the effect of ...

Introduction: Leiomyoma are benign mesenchymal tumors presenting as the most common uterine neoplasm. Atypical leiomyoma (ALM), a nomenclature given in WHO classification, is a leiomyoma variant showing histopathological features ranging between a benign leiomyoma and leiomyosarcoma (LMS). It is a rare smooth muscle neoplasm detected mostly on histological examination in myomectomy and hysterec...