Background. Hereditary gingival fibromatosis is a fibrotic enlargement of the gingiva. It may exist as an isolated abnormality or as part of multisystem syndrome. This paper reports a case of 16-year-old male with generalized severe gingival overgrowth, involving the maxillary and mandibular arches and covering almost all teeth. Methods. Periodontal management of gingival enlargement included g...

Background. Hyaline fibromatosis syndrome is a rare, highly dramatic, autosomal recessive multisystem disorder. The basis of the disease abnormal diffuse deposition hyaline material in connective tissue and internal organs. Mutations CMG2 gene (also known as ANTXR2 gene) cause disease. encodes transmembrane protein involved endothelial development. involves two allelic diseases that have same p...