Nine patients with 11 beta-hydroxylase deficiency had 13 episodes of gastroenteritis requiring hospital admission and fluid administration. Eight episodes were accompanied by hyponatraemia and salt loss. The salt losing patients were treated with excessive glucocorticoid and those with normal serum sodium concentrations were treated with inadequate glucocorticoid. Excessive glucocorticoid suppr...

In patients with advanced bladder cancer, glucocorticoids are frequently given to reduce acute toxicity, particularly hyperemesis, during chemotherapy, as well as to improve cachectic conditions. However, it remains unclear whether glucocorticoids directly affect the development and progression of bladder cancer through the glucocorticoid receptor pathway. Glucocorticoid receptor expression was...

Glucocorticoid-resistant mutants isolated form the glucocorticoid-sensitive human leukemic cell line CEM-C7 can be divided into three phenotypes: those with almost no glucocorticoid-binding activity (r-); those whose steroid-receptor complexes are unstable during attempted activation but are stabilized by the presence of sodium molybdate (actl:molybdate-sensitive); and those whose steroid-recep...

OBJECTIVE Previous theories have emphasized the role of excessive glucocorticoid activity in the pathology of chronic stress. Nevertheless, insufficient glucocorticoid signaling (resulting from decreased hormone bioavailability or reduced hormone sensitivity) may have equally devastating effects on bodily function. Such effects may be related in part to the role of glucocorticoids in restrainin...

The glucocorticoid dexamethasone prevents nausea and vomiting after surgery, but there is concern that it may increase the risk of surgical-site infection.

• Corticosteroids function to optimize the stress response and are thus essential for the organism to cope with the stressor. • Corticosteroid signaling is mediated by two receptors: the high-affinity mineralocorticoid receptor and the low-affinity glucocorticoid receptor. • Imbalance between central glucocorticoid and mineralocorticoid receptor affects the secretion of corticosteroids and has ...

Mục tiêu: Nhận xét thực trạng tăng đường huyết sau tiêm trưởng thành phổi tại bệnh viện Phụ Sản Hà Nội năm 2022. Phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 50 nhân đái tháo thai kỳ (ĐTĐTK) có chỉ định glucocorticoid để nhi sản từ tháng 1 đến 10 Kết quả: Tỷ lệ phụ các giá trị glucose máu không đạt mục tiêu cao glucocorticoid, nhất trong ngày thứ 2 và 3 ở hơn 80% giảm dần 7. luận: Sa...

OBJECTIVES We studied oral glucocorticoids and osteonecrosis, a rare but serious bone disease, in individuals with various chronic inflammatory diseases. We hypothesised that we would find stronger associations in adults versus children and in people with autoimmune diseases. DESIGN Retrospective cohort study. SETTING Population-representative data (1994-2013) from general practices in the ...