BACKGROUND Anal fissure is a linear tear in the distal anal canal resulting from persistent hypertonia and spasm of the internal sphincter which results in mucosal ischemia. We have conducted a study in order to compare the outcome of 0.2% glyceryl trinitrate cream versus 2% diltiazem cream in the treatment of chronic anal fissure. METHODS This randomized controlled trial (RCT) was carried ou...

OBJECTIVE To further resolve the clinical equipoise on the choice of chemical sphincterotomy agent for early symptomatic relief of anal fissure by comparing the effectiveness of 2% Diltiazem gel with 0.2% Glyceryl TriNitrate. METHODS The randomized clinical trial was conducted at Aga Khan University Hospital, Karachi, from February 1, to July 30, 2008, and comprised 60 adult patients with ana...

Cereal Chem. 71(6):582-587 Commercial corn starches containing 0-70% amylose were extruded formation of complexes between amylose and lipids. Maximum binding with and without various lipids (myristic, stearic, and behenic acids; monowas observed for myristic acid and 70% amylose starch. No binding was glyceride Dimodan PV; and tristearin) in a single-screw laboratory observed with tristearin. P...

Previously, it was shown that the D enantiomer of isoidide dinitrate was 10-fold more potent than the L enantiomer and 10-fold less potent than glyceryl trinitrate for stimulating cyclic GMP accumulation and relaxation of isolated rat aorta. In the present study, these organic nitrates were tested for their ability to induce tolerance to organic nitrate-induced relaxation, cyclic GMP accumulati...

Labeled long chain acyl-CoA, aldehyde, and alcohol (16:0) were incubated in the peritoneal cavity of mice bearing Ehrlich ascites cells and the distribution of radioactivity in the acyl, alkyl, and alk-1-enyl moieties of various neutral lipid and phospholipid classes was compared. The results suggested the following metabolic relations. 1. Alkyl glyceryl ethers are precursors of alk-l-enyl glyc...

Glyceryl trinitrate is a weak inhibitor of platelet aggregation in vitro. Its effect on platelet aggregation in response to U46619 (a thromboxane/endoperoxide receptor agonist) was studied turbidometrically in platelet-rich plasma from healthy volunteers. The object was to determine whether inhibition was influenced by a period of preincubation between preparation of platelet-rich plasma and ad...

Labeled long chain acyl-CoA, aldehyde, and alcohol (16:0) were incubated in the peritoneal cavity of mice bearing Ehrlich ascites cells and the distribution of radioactivity in the acyl, alkyl, and alk-1-enyl moieties of various neutral lipid and phospholipid classes was compared. The results suggested the following metabolic relations. 1. Alkyl glyceryl ethers are precursors of alk-l-enyl glyc...

The effects of intravenous infusions of glyceryl trinitrate and nifedipine on systemic haemodynamic function, coronary haemodynamic function, and global myocardial metabolism were compared in two groups of eleven patients with unimpaired left ventricular function undergoing elective coronary artery operation who were anaesthetised with high dose fentanyl. Severe post-sternotomy hypertension dev...

OF all the methods of delaying the absorption of intramuscular penicillin, combination with procaine is at present foremost (Florey 1952). Procaine penicillin is most effective when the particles are smaller than 5 µ and are suspended in a peanut-oil medium with 2% (w/v) aluminium monostearate (Thomas et al. 1948). Emery et al. (1949) showed that in children a serum-penicillin level above...