Traditionally, glycyrrhizic acid has been used to form polydentate complexes. For the first time in presented paper, complexation of Plant’s Flavonoids (Quercetin (Qu) and its glycoside - Rutin (Rut)) with novel Russian antiviral drug Camphecene (Camph) was investigated. The complexes obtained at different molar ratios were studied using UV/Vis spectroscopy. Formation host: guest registered: Qu...

Hyaluromycin (1), a new member of the rubromycin family of antibiotics, was isolated from the culture extract of a marine-derived Streptomyces sp. as a HAase inhibitor on the basis of HAase activity screening. The structure of 1 was elucidated through the interpretation of NMR data for the compound and its 3″-O-methyl derivative in combination with an incorporation experiment with [1,2-13C2]ace...

Glycyrrhizin decreased the resistance of intact male mice to prolonged exposure to cold (8 hours at 5 degrees C.) and it decreased the ability of intact male rats to mobilize glucose when subjected to 48 hours of fasting. It is suggested that glycyrrhizin, like desoxycorticosterone, depresses the output of ACTH.

The rate-limiting enzyme in the mevalonic acid (MVA) pathway which can lead to triterpenoid saponin glycyrrhizic acid (GA) is 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR). In order to reveal the effect of copy number variation in the HMGR gene on the MVA pathway, the HMGR gene from Glycyrrhiza uralensis Fisch. (GuHMGR) was cloned and over-expressed in Pichia pastoris GS115. Six recombinant P...

A rapid and simple method for the simultaneous determination of twelve sweeteners and nine preservatives in various foods by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed. The sweeteners and preservatives were extracted from solid samples with 80% and 50% methanol and from liquid samples with 80% methanol, followed by Oasis WAX cartridge cleanup. The LC separation was ...

It was demonstrated by the present study that glycyrrhizin inhibited the action of estradiol-17ƒÀ on uterine weight and ƒÀ-glucuronidase activity in ovariectomized mice and rats in a certain dose ratio. The inhibition was 50% or more when the dose ratio of glycyrrhizin: estradiol-17(3 was 1000: 1. In any higher ratio of glycyrrhizin to estrogen, the inhibition was decreased or even reversed. Gl...