The vascular beds of the upper or lower body of rats were perfused through the aorta with oxygenated Krebs-Ringer solution containing dextran (7 g/100 ml), at 37 degrees C. Perfusion was stopped every 10 minutes, and the pressure rise in the jugular or the femoral vein was recorded during rapid infusion (15.3-90.0 ml/min) of Krebs-Ringer solution into the inferior vena cava. The following group...

INTRODUCTION Ghrelin, an appetite-stimulating hormone secreted by the endocrine cells of the gastrointestinal (GI) tract, has recently been shown to affect the function of the cardiovascular system. This study aimed to assess the number and morphology of ghrelin-immunopositive (GhrIP) cells in the gastrointestinal tract of rats at different developmental phases of experimentally evoked renovasc...

Bright in 1836 first described the course of chronic nephritis, and Mahomed in 1874 in his Paper entitled 'The Pre-albumenuric Stage of Bright's Disease' drew attention to the association of this disease with high arterial tension. It has since been well established that renal disease of many kinds predisposes to arterial hypertension (Longcope and Winkenweider, 1933; Pickering and Heptinstall,...

The major issues in approaching patients with renal artery stenosis relate to the role of renal artery stenosis in the management of hypertension, ie, “renovascular hypertension,” and to the potential for vascular compromise of renal function, ie, “ischemic nephropathy.” Ever since the original Goldblatt experiment in 1934, wherein experimental hypertension was produced by renal artery clamping...

Surgical correction of renal artery stenosis in Goldblatt hypertension rapidly normalizes blood pressure and increases renal function. This study was conducted in 1-kidney, 1 clip (1K1C) Goldblatt hypertensive rats to examine whether the unclipping-induced reversal of blood pressure and renal function is mediated by nitric oxide (NO). The 1K1C rats were prepared and given tap water with or with...

• The cause of hypertension in human coarctation of the aorta is not well understood. The proponents of a mechanical hypothesis" suggest that the increase in blood pressure is due to the resistance offered by the coarctation and the collateral circulation, whereas those favoring a humoral explanation" postulate the existence of a generalized increase in peripheral resistance such as occurs in r...