Scavenger receptor BI (SR-BI) is an HDL receptor. It binds HDL and mediates the uptake of cholesteryl ester from HDL. Early studies have pointed out that the extracellular domain of SR-BI is critical for SR-BI-mediated cholesteryl ester uptake. However, the extracellular loop of SR-BI is large: it contains 403 amino acids. The HDL binding site and the modulation of SR-BI-mediated cholesteryl es...

In this paper, we initiate the study of prime bi-ideals (fuzzy bi-ideals) in semirings. We define strongly prime, prime, semiprime, irreducible and strongly irreducible bi-ideals in semirings. We also define strongly prime, semiprime, irreducible, strongly irreducible fuzzy bi-ideals of semirings. We characterize those semirings in which each bi-ideal (fuzzy bi-ideal) is prime (strongly prime).

in this paper we define ( , ) k  q -fuzzy h -sub hemirings, ( , ) k  q -fuzzy h -ideals, ( , ) k  q - fuzzy     h -bi-ideals and ( , ) k  q -fuzzy h -quasi-ideals. we characterize h -hemiregular and h -intrahemiregular hemirings by the properties of their     ( , ) k  q -fuzzy h -ideals, ( , ) k  q -fuzzy h -bi-ideals and     ( , ) k  q -fuzzy h -quasi-...

The design of robust new interfaces that process conversational speech is a challenging research direction largely because users’ spoken language is so variable, which is especially true of children. The present research explored whether children’s response latencies before initiating a conversational turn converge with those heard in the text-to-speech (TTS) of a computer partner. A study was ...

We developed a chiral 1,1'-bi-2-naphthol-bridged imidazole dimer possessing 100 μs fast photochromism and high fatigue resistance. It offers great opportunities for the practical applications to fast photoresponsive chiral dopants, invisible security materials and optical trigger molecules to induce the dynamic structural changes in biological matters.

Concomitant inhibition of multiple cancer-driving kinases is an established strategy to improve the durability of clinical responses to targeted therapies. The difficulty of discovering kinase inhibitors with an appropriate multitarget profile has, however, necessitated the application of combination therapies, which can pose major clinical development challenges. Epigenetic reader domains of t...

Various epoxides are converted to their corresponding thiiranes in excellent yields with ammonium thiocyanate and thiourea under non-aqueous conditions in the presence of catalytic amounts of Bi(TFA)3 and Bi(OTf)3.

Introduction Breast cancer continues to be an important health problem. Early detection is needed to improve prognosis and significantly reduce women mortality. Computer-Aided Diagnosis systems (CAD) can help radiologist to improve their ability to detect and classify breast lesions. However, automated interpretation of mammogram lesions still remains very difficult. Some of the reasons are the...

Scavenger receptor class B type I (SR-BI) mediates the selective uptake of HDL cholesteryl esters (CEs) and facilitates the efflux of unesterified cholesterol. SR-BI expression in macrophages presumably plays a role in atherosclerosis. The role of SR-BI for selective CE uptake and cholesterol efflux in macrophages was explored. Macrophages and HDL originated from wild-type (WT) or SR-BI knockou...