نتایج جستجو برای: gp63
تعداد نتایج: 204 فیلتر نتایج به سال:
The major surface protease (MSP or GP63) in the intracellular amastigote stage of Leishmania chagasi
A T-cell clone (designated KLmB-3) was derived from resistant C3H mice 2 weeks after infection with Leishmania major. KLmB-3 was a CD4-T-cell clone that utilized the V beta 8.1 T-cell receptor. When adoptively transferred to naive C3H mice, KLmB-3 unexpectedly exacerbated infection with L. major (it increased the cutaneous lesion size and the parasite burden within the lesion). The ability of K...
BACKGROUND Leishmaniasis is a neglected disease affecting millions of people worldwide. The treatment of the disease is hampered due to high cost, toxicity and the crisis of drug resistance. Polytope approaches of genetic immunization could be a strategy for prevention of infectious diseases. Furthermore, the identification of Leishmania genome sequence and the application of bioinformatics ass...
The use of a computational approach to drug discovery has paved way towards polypharmalogical advancement and the improvement of existing drugs. The methods of docking, virtual screening, and active site similarity search were used to identify possible natural and synthetic compounds from the NADI (Nature-Based Drug Discovery Resource) and the NCI Diversity Set II databases that may exhibit fav...
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