Macrophages as immune cells prevent the spreading of pathogens by means of active phagocytosis and killing. We report here the presence of an antimicrobial protein, bactericidal/permeability-increasing protein (BPI) in human macrophages, which actively participates in engulfment and killing of Gram-negative pathogens. Our studies revealed increased expression of BPI in human macrophages during ...

Background and Aims: Urinary tract infections are one of the most common human infections seen in all age groups and both sexes. Inappropriate use of antibiotics to treat urinary tract infection causes the resistance of the pathogens to the drug. The present study aimed to determine the frequency of gram-negative and gram-positive bacteria and antibiotic resistance patterns in patients with uri...

conclusions our findings implied that a wide range of bacteria could be involved in creating urinary tract infection in patients referred to a medical laboratory of kashani and hajar hospital in shahrekord, iran. regardless of age, sex and the use of catheter, a wide range of bacteria could be involved in urinary tract infections. patients and methods in this cross-sectional study 147 urine sam...

background and objectives: non-fementer gram-negative bacilli (nfgb) are ubiquitous pathogen that has emerged as a major cause of health care associated infections. the aim of this study was to determine the prevalence and antimicrobial susceptibility of   nfgb in an iranian hospital. materials and methods: fromjuly 2005 to november 2006 a total of 257 strains of nfgb including 109 (42.41%) str...

conclusions our results showed the rate of effects of different risk factors on imipenem resistance. regarding the studied risk factors, appropriate programs must be set in place to control and prevent imipenem resistance in gram-negative bacteria. results of the 374 isolated, 134 were imipenem resistant, and 240 were sensitive to imipenem. the resistance rate was more common in males and in pa...

PURPOSE The purpose of this study is to investigate the distribution and antimicrobial susceptibility of pathogenic bacteria in inpatients with pulmonary infection in the neurological intensive care unit (NICU). METHODS A total of 947 sputum specimens of 428 inpatients from May 2007 to May 2008 in the NICU were enrolled in the study, and bacterial identification and antibiotic susceptibility ...