The purpose of this research work was to develop and evaluate a chronotherapeutic based colon-targeted drug delivery system of theophylline (THEO) exploiting pH-enzyme sensitive property for the prevention of episodic attack of asthma in early morning. Guar gum microspheres of theophylline were prepared by emulsification technique. Coating of microspheres was performed using solvent evaporation...

Genetic improvement in industrially important guar (Cyamopsis tetragonoloba, L. Taub.) crop has been hindered due to the lack of sufficient genomic or transcriptomic resources. In this study, RNA-Seq technology was employed to characterize the transcriptome of leaf tissues from two guar varieties, namely, M-83 and RGC-1066. Approximately 30 million high-quality pair-end reads of each variety ge...

The ideal water-soluble dietary fiber for the fiber-enrichment of foods must be very low in viscosity, tasteless, odorless, and should produce clear solutions in beverages. Partially hydrolyzed guar gum (PHGG) produced from guar gum by enzymatic process has the same chemical structure with intact guar gum but less than one-tenth the original molecular length of guar gum, which make available to...

The present study was aimed to develop and evaluate Albendazole microcapsules using guar gum, a natural polymer for colon-specific delivery for better treatment of Helminthiasis, Filariasis, and colorectal cancer by avoiding the side effects. Microcapsules were prepared by the use of different concentrations of sodium alginate and guar gum. The polysaccharides guar gum reacted with sodium algin...

PURPOSE OF STUDY: In the present study, an attempt was made to increase therapeutic effectiveness, reduction in dosing frequency and thus improving patient compliance, by developing sustained release matrix tablets of Diclofenac sodium using guar gum as release modifier. METHOD: Six batches of sustained release matrix tablets of Diclofenac sodium was prepared by using different drug: polymer ra...

PURPOSE To investigate the characteristics of ocular surface sensations and corneal sensitivity during the interblink interval before and after tear supplementation in dry eye patients. METHODS Twenty subjects (41.88±14.37 years) with dry eye symptoms were included in the dry eye group. Fourteen subjects (39.13±11.27 years) without any clinical signs and/or symptoms of dry eye were included i...

Guar gum can be used to effectively improve stability and mobility of microscale zerovalent iron particles (MZVI) used in groundwater remediation. Guar gum is a food-grade, environment friendly natural polysaccharide, which is often used as thickening agent in a broad range of food, pharmaceutical and industrial applications. Guar gum solutions are non-Newtonian, shear thinning fluids, characte...

BACKGROUND/AIMS In the present study, we aimed to investigate if partially hydrolyzed guar gum (PHGG) can be used safely as a fiber source for treatment of constipation in children and to compare its success with the most commonly used osmotic laxative, lactulose. METHODS A randomized prospective controlled study on 61 patients (partially hydrolyzed guar gum group, n: 31; lactulose group, n: ...

It generally is accepted that a diet high in fiber, decreased dietary fat content were present. Thus, it has not been possible to determine if dietary fiber was patticularly soluble fiber, is useful in the management playing a significant role. The of studies in of the plasma glucose concentration in individuals with diabetes. This is one of the reasons several which specific, defined fibers ha...