We assessed the effects of in vivo phototherapy of Gunn rats on the activity of hepatic microsomal mixed-function monoxygenases and on the in vivo pharmacokinetics of [14C]HB. In experiment 1 no serial changes were seen in activities of hexobarbital hydroxylase or benzo(a)pyrene hydroxylase in hepatic microsomes isolated after 2, 4 or 7 days from homozygous jaundiced female Gunn rats exposed to...

Kernicterus is known to produce damage to the auditory system and the basal ganglia in humans. Although the Gunn rat model of kernicterus has been extensively used to characterize the auditory features, this model has not been similarly utilized to systematically investigate the movement disorder. In the present study, spontaneously jaundiced (jj) 16 day old Gunn rat pups were treated with sulf...

Mildly elevated bilirubin is associated with a reduction in the presence and progression of chronic kidney disease and related mortality, which may be attributed to bilirubin's antioxidant properties. This study investigated whether endogenously elevated bilirubin would protect against adenine-induced kidney damage in male hyperbilirubinaemic Gunn rats and littermate controls. Animals were oral...

Isolated surgical lesions were made in three Macaca mulatta monkeys. Two had right optic tract section. One control underwent section of the right half of the chiasm. Preoperative evaluation revealed no fundus, pupil, or VER abnormalities. Postoperatively, a classic Marcus Gunn pupil was found contralateral to the isolated optic tract lesions. The control had normal pupils. The nature of the le...

CONGENITAL ptosis in association with jaw-winking is a clinical entity in which the ptosis disappears and the lid retracts on opening the mouth, or on moving the jaw to the opposite side. This condition, known as the Marcus Gunn phenomenon (Gunn, 1883), has been noted in association with paralysis of the superior rectus (Proskauer, 1891; Goldzeiher, 1892), internal rectus (Uhthoff, 1888), exter...

THE Gunn rat is an animal model for Crigler-Najar syndrome. a rare form of congenital unconjugated nonhemolytic hyperbilirubinemia due to the absence of glucoronyl transferase. I.e It leads to deposition of bilirubin in the basal ganglia. culminating in precocious death of the patient. Because the uptake. conjugation. and excretion of bilirubin by hepatocytes involves specific carriers and enzy...

BACKGROUND AND AIMS Preparative hepatic irradiation (HIR), together with mitotic stimulation of hepatocytes, permits extensive hepatic repopulation by transplanted hepatocytes in rats and mice. However, whole liver HIR is associated with radiation-induced liver disease (RILD), which limits its potential therapeutic application. In clinical experience, restricting HIR to a fraction of the liver ...

Certain equations with integral constraints have as solutions time-periodic pulses of a field-like unknown while a current-like unknown oscillates periodically with time. A general asymptotic theory of this phenomenon, the generalized Gunn effect, has been found recently. Here we extend this theory to the case of nonlinearities having only one stable zero, which is the case for the usual Gunn e...

The dynamics of a system comprising of two bilaterally coupled Gunn oscillators (BCGOs) has been examined using a circuit theoretic model of the Gunn oscillator (GO). The effects of coupling factors (kij ) between i-th and j-th oscillators on the frequency-range of synchronized operation and the magnitude of common frequency of oscillation have been examined semi-analytically and by numerical s...

GaAs-based Gunn diodes with graded AlGaAs hot electron injector heterostructures have been developed under the special needs in automotive applications. The fabrication of the Gunn diode chips was based on total substrate removal and processing of integrated Au heat sinks. Especially, the thermal and RF behavior of the diodes have been analyzed by DC, impedance and S-parameter measurements. The...