imatinib is an orally administered tyrosine kinase inhibitor which inhibits the bcr-abl protein-tyrosine kinase with high selectivity. imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. the metabolism of imatinib is mediated by the cytochrome p450 (cyp) isoenzymes in the liver and gut wall. cgp74588 is a major active metabolite of ima...

Postprandial hyperlipidemia (PH) is recognized as a significant risk factor for cardiovascular disease. The present study, involving rats with streptozotocin (STZ)-induced diabetes, was performed to establish a PH model and to examine the relation between small intestinal acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity and serum lipid levels in the postprandial state. The small inte...

It is generally accepted that the gut plays an essential role in the water economy of marine and seawater-acclimated teleosts, water losses being balanced by continuous ingestion of drinking water (e.g. Maetz, 1970). Desalting of the ingested sea water (SW) takes place in the oesophagus, which is very permeable to Na and Cl but relatively impermeable to water, and Na, Cl and water resorption co...

Digestive systems of deposit and suspension feeders can be exposed to high concentrations of copper (Cu) by ingestion of contaminated sediments. We assessed a potential impact of this Cu exposure on digestive enzyme activities in a wide range of benthic organisms by monitoring enzyme activities in their gut fluids during in vitro titrations with dissolved Cu, which mimics Cu solubilization from...

The large number of probiotic products now available makes the decision about which product to choose difficult both for the consumer and for the specialist providing dietary/nutritional advice. Data on the viability of the bacteria in these products, in an in vivo situation, are therefore important. This study was designed to explore the comparative health and survival of probiotic species in ...

The digestion and absorption of collagen, native and artificially cross-linked, has been examined in the rat and the Gaboon viper, by feeding known quantities and measuring the hydroxy-proline content of the faeces and of the contents of the gut at different levels, and comparing with an unabsorbable marker (polyethylene glycol). Incubation of collagen in vitro with pepsin at 37 degrees C at pH...

INTRODUCTION It has been shown that the pleroceroid larvae of the bird cestode Schistocephalus solidus matures rapidly when cultured aseptically in suitable media at 40 C. provided pH and oxygen tension are controlled (Smyth, 1946, 1950). This temperature of 40° C. represents the average body temperature of birds, in the gut of which pleroceroids normally develop (Hopkins & Smyth, 1952). It is ...

Ingested pollutants may elicit digestive toxicity following incorporation into consumer tissues. This post-assimilatory toxicity may include tissue damage influencing synthesis of digestive enzymes, gut transit time and absorption of nutrients as well as pollutants by the gut epithelium. This study investigated impacts of chronic field exposure on gut residence time (GRT), feces elimination rat...

Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...