A general haploid selection model with arbitrary number of multiallelic loci and arbitrary linkage distribution is considered. The population is supposed to be panmictic. A dynamically equivalent diploid selection model is introduced. There is a position effect in this model if the original haploid selection is not multiplicative. If haploid selection is additive then the fundamental theorem is...

GENECLASS2 is a software that computes various genetic assignment criteria to assign or exclude reference populations as the origin of diploid or haploid individuals, as well as of groups of individuals, on the basis of multilocus genotype data. In addition to traditional assignment aims, the program allows the specific task of first-generation migrant detection. It includes several Monte Carlo...

The development of forward genetic screens in human haploid cells has the potential to transform our understanding of the genetic basis of cellular processes unique to man. So far, this approach has been limited mostly to the identification of genes that mediate cell death in response to a lethal agent, likely due to the ease with which this phenotype can be observed. Here, we perform the first...

The recently elucidated definition of fitness employed by Fisher in his fundamental theorem of natural selection is combined with reproductive values as appropriately defined in the context of both random environments and continuing fluctuations in the distribution over classes in a class-structured population. We obtain astonishingly simple results, generalisations of the Price Equation and th...

Deleterious mutations can accumulate in asexual haploid genomes through the process known as Muller's ratchet. This process has been described in the literature mostly for the case where all mutations are assumed to have the same effect on fitness. In the more realistic situation, deleterious mutations will affect fitness with a wide range of effects, from almost neutral to lethal. To elucidate...

The problem of moving from one coadapted gene complex to a better one can be divided into two steps: first the advantageous combination has to appear and then it has to take over the population. Selection can have contrasting effects on the two stages. When selection is weak intermediate forms are frequent, and the advantageous combination appears easily. Spreading of that advantageous combinat...

Variability in the way organisms reproduce raises numerous, and still unsolved, questions in evolutionary biology. In this study, we emphasize that fungi deserve a much greater emphasis in efforts to address these questions because of their multiple advantages as model eukaryotes. A tremendous diversity of reproductive modes and mating systems can be found in fungi, with many evolutionary trans...

Two mutants of Saccharomyces cerevisiae have been isolated from normal haploid MAT alpha strains and characterized as having temperature-sensitive, pleiotropic phenotypes for functions associated with mating. At the permissive temperature, 23 degrees C, they were found to behave as normal MAT alpha haploids with respect to mating efficiency, sporulation in diploids formed with MAT a strains, se...

The fission yeast Schizosaccharomyces pombe exists in one of two mating types (Plus or Minus) and conjugation between two haploid cells is controlled by the reciprocal action of diffusible mating pheromones (for review, see 1). Thus, a P-cell releases P-factor and responds to M-factor since it expresses the M-factor receptor while an M-cell releases M-factor and responds to P-factor. Exposure t...

In the Funding section, the grant number from the funder National High Technology Research and Development Program in China is listed incorrectly. The correct grant number is: 2012AA10A408-05. Copyright: © 2016 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any...