Adhyperforin is a novel constituent of Hypericum perforatum L., but its antidepressant-like activity remains unclear. To explore that, several well-validated animal models of depression as well as neurotransmitter reuptake and transporter binding assays were conducted. The results showed adhyperforin could reduce the immobility time of mice in the forced swimming test and tail suspension assay,...

Hypericum perforatum is an herb whose use dates back centuries. Extracts of the plant are available as over-the-counter treatment options for depression. The genus consists approximately 500 species, most which have not yet been studied. Antimicrobial resistance has reached alarming levels, indicating a post-antibiotic era many become less effective. For this reason, nine species were studied t...

Hypericum perforatum (HP), better known as St. John's Wort, has been used clinically for centuries. Modern usage is still quite diverse and includes kidney and lung ailments, insomnia and depression. Standardised extracts of HP are widely used in the treatment of psychovegetative disorders and especially for mild forms of depression. Several bioactive constituents of this plant may play importa...

Amaç: Bitkilerden elde edilen uçucu yağlar, geleneksel sentetik böcek öldürücülere çevre dostu alternatifler sağlayabilir. Bu çalışmada beş farklı esansiyel yağın (Thymus vulgaris, Piper nigrum, Syzygium aromaticum, Hypericum perforatum, Papaver somniferum) Musca domestica larvalarına karşı etkisinin değerlendirilmesi amaçlanmıştır. Yöntem: Her yağ çeşidinin üç dozu (% 1, % 3 ve 6) tekerrürlü o...

The Iowa Center for Research on Botanical Dietary Supplements seeks to optimize Echinacea, Hypericum, and Prunella botanical supplements for human-health benefit, emphasizing antiviral, anti-inflammatory and anti-pain activities. This mini-review reports on ongoing studies on Hypericum. The Center uses the genetically diverse, well-documented Hypericum populations collected and maintained at th...

Reverse transcription-quantitative real-time PCR (RT-qPCR) is a widely used technique for gene expression analysis. The reliability of this method depends largely on the suitable selection of stable reference genes for accurate data normalization. Hypericum perforatum L. (St. John's wort) is a field growing plant that is frequently exposed to a variety of adverse environmental stresses that can...

Hypericin is a pigment present in the widely distributed medicinal plant Hypericum perforatum L. (Hypericaceae). In our research, hypericin was found to be an inhibitor of NADPH/Fe 2+ induced microsomal lipid peroxidation and NADPH-dependent lucigenin chemiluminescence emission in vitro. Hypericin also inhibited the microsomal CYP1Adependent 7-ethoxyresorufin O-deethylase (EROD) which participa...

The alcoholic extract of the shoot of H. perforatum shows strong antioxidant property. It possesses the iron chelation property with more affinity to the ferrous form. It has scavenging property for both superoxide and for hydroxyl radicals but the response is more towards the superoxide radicals. Thus in addition to the anti-depressant property it has strong antioxidant property also.