AIMS HaemoglobinA1c (HbA1c) is recommended for diabetes diagnosis but fasting plasma glucose (FPG) has been useful for identifying patients with glucokinase (GCK) mutations which cause lifelong persistent fasting hyperglycaemia. We aimed to derive age-related HbA1c reference ranges for these patients to determine how well HbA1c can discriminate patients with a GCK mutation from unaffected famil...

HbA1c has been recommended as a test option for the diagnosis of diabetes by both the American Diabetes Association (1) and the World Health Organization (WHO) (2). Both organizations advised that after a result consistent with the diagnosis of diabetes ($6.5% [48 mmol/mol]), HbA1c levels should be repeated in asymptomatic patients within 2 weeks to rule out the rare occurrence of a sample bein...

For glucose-lowering drugs inducing hypoglycemia, a marginally protective effect on the risk of MACE was observed for HbA1c 48-58 mmol/mol, whereas significant reduction microvascular complications HbA1c<49 but with higher severe hypoglycaemia. Drugs not hypoglycaemia were associated MACE, renal adverse events, and all-cause mortality, HbA1c<7% (no data lower targets). Conclusions: presen...

Glycated hemoglobin (HbA1c) has recently been recommended for the diagnosis of type 2 diabetes mellitus (T2DM) by leading diabetes organizations and by the World Health Organization. The most important reason to define T2DM is to identify subjects with high risk of diabetes complications who may benefit from treatment. This review addresses two questions: 1) to assess from existing studies whet...

Glycated haemoglobin A1c (HbA1c) gives an integrated plasma glycaemia for the previous 2-3 months and its measurement is central in the management of diabetic patients. However in many developing countries because kits/regents or expertise for HbA1c measurement are not always available and the test must be conducted on fresh whole blood samples, HbA1c tests are not routinely performed Thus, thi...

Introduction American Diabetes Association (ADA) has officially endorsed glycosylated haemoglobin (HbA1c) as a diagnostic tool. The recommended cut-off for diagnosing diabetes is  6.5%. Objectives To compare use of HbA1c and fasting plasma glucose (FPG) to diagnose diabetes in an urban Sri Lankan community. Methods This cross-sectional study is based on baseline data from a prospective stu...

BACKGROUND Diabetes is associated with increased cancer risk. The underlying mechanisms remain unclear. Hyperglycemia might be one risk factor. HbA1c is an indicator of the blood glucose level over the latest 1 to 3 months. This study aimed to investigate association between HbA1c level and cancer risks in patients with type 2 diabetes based on real life situations. METHODS This is a cohort s...

BACKGROUND Hemoglobin A1C (HbA1C) is associated with increased risk of cardiovascular events, but its use for prediction of cardiovascular disease (CVD) events in combination with conventional risk factors has not been well defined. METHODS AND RESULTS To understand the effect of HbA1C on CVD risk in the context of other CVD risk factors, we analyzed HbA1C and other CVD risk factor measuremen...

BACKGROUND The investigation of glycated hemoglobin (HbA1c) as a diagnostic tool for abnormal glycometabolism is lack in acute ischemic stroke patients in China and worldwide. This paper was aimed to determine whether HbA1c, fasting plasma glucose (FPG), or HbA1c combined with FPG, could be used to screen for diabetes mellitus (DM) or prediabetes in acute ischemic stroke patients without previo...

in this case study, we describe a 25 year-old male who showed the symptoms of diabetes after a period of heavy drinking. (hba1c=13%). treatment was started with 120 units of insulin. after stopping alcohol consumption and taking an appropriate diet, insulin was tapered down. five months after the start of treatment, insulin was stopped (hba1c=5%). the results showed that he was in a good metabo...