BACKGROUND The purpose of this study was to characterize somatic mutations in the D-loop of mitochondrial DNA (mtDNA) and their impact on survival in patients with head and neck cancer. METHODS Histologically confirmed head and neck cancer and corresponding noncancerous tissues were obtained from 130 patients. The D-loop of mtDNA sequence in noncancerous tissues was compared with that of pair...

Squamous cell carcinoma of larynx is one the most common malignant neoplasms head and neck. Carcinoma represents 2.2% all cancers in men 0.4% women, with predilection old aged more than 50 years rather women. Smoking main risk factor. Alcohol, nutritional factors virus as Human papillomavirus (HPV) play a role pathogenesis laryngeal carcinoma. Programmed death-ligand (PDL1) new introduced marke...

Squamous cell carcinoma (SCC) of the oral cavity is one most common malignancies head and neck. Risk factors for development SCC include infection with human papillomavirus (HPV), tobacco use, alcohol use. HPV-positive more commonly seen in young adult patients, whereas HPV-negative disease prevalent older patients histories We describe case a an extensive history vaping using nicotine-delivery...

To establish a genetic model of the progression of head and neck squamous carcinoma we have defined the incidence and timing of p53 mutations in this type of cancer. We sequenced the conserved regions of the p53 gene in 102 head and neck squamous carcinoma lesions. These included 65 primary invasive carcinomas and 37 noninvasive archival specimens consisting of 13 severe dysplasias and 24 carci...

HNSCC: head and neck SCC SCC: squamous cell carcinoma SSS: secondary SCC of the skin INTRODUCTION Metastatic squamous cell carcinoma (SCC) to the skin, also known as secondary SCC of the skin (SSS), is a rare entity that represents advanced disease and carries a poor prognosis. The most commonly reported primary sources for metastatic SCC to the skin are head and neck cancers of the larynx, oro...

Head and neck cancer is the sixth most common worldwide. The single important factor affecting prognosis for squamous cell carcinoma status of cervical lymph nodes. Metastasis to regional nodes reduces 5-year survival rate by 50% compared with that patients early-stage disease. American society reports 40% oral cavity pharynx present metastases This activity presents steps safe optimum dissecti...

HER-3 expression has been reported to act as an important oncoprotein in head and neck squamous cell carcinoma. This protein is known to control tumor proliferation and acquisition of resistance by tumor cells towards EGFR inhibitors, therefore, development of a HER-3-targeted therapy is desirable. In this study, we found that HER-3 expression on tumor cells was increased after EGFR inhibition....

Background and Aim: Basal cell carcinoma (BCC) is considered to be the most common malignancy in humans and occurs primarily in the skin especially in the head and neck region. Considering the high recurrence rate of the tumor, finding a marker for prediction of recurrence is very important. Cancer stem cells are a small subpopulation in the tumors that are related to tumorigenesis and recurren...

background: the locally advanced head and neck cancer with fixed nodes are incurable and has a short survival. this study aims to evaluate the symptom relief, disease response and acute toxicity after palliative hypofractionated radiotherapy. methods: between december 2010 to june 2011, previously untreated 50 patients who had histopathologically proved of head and neck squamous cell carcinoma ...

The International Agency for Research on Cancer has classified radiofrequency radiation as possibly carcinogenic. Previous studies have focused on intracranial tumors, although the skin receives much radiation. In a nationwide cohort study, 355,701 private mobile phone subscribers in Denmark from 1987 to 1995 were followed up through 2007. We calculated incidence rate ratios (IRRs) for melanoma...