نتایج جستجو برای: heart contractility
تعداد نتایج: 396124 فیلتر نتایج به سال:
The effects of intravenous and sublingual glyceryl trinitrate (nitroglycerin), 40 mug/kg, were studied on coronary blood flow and resistance, left ventricular (LV) pressures (P) and diameters (D), rate of change of pressure (dP/dt), (dP/dt)/P, and on the velocity (V) of myocardial fiber shortening in conscious dogs. Nitroglycerin i.v. caused substantial coronary vasodilatation prior to any chan...
Several indexes of myocardial contractility have been proposed to assess ventricular function in the isovolumetrically beating isolated heart. However, the conclusions reached on the basis of these indexes may be influenced by ventricular geometry rather than contractility itself. The objective of the present study was to assess the performance of widely used contractility indexes in the isovol...
Vasopressors and inotropes are often administered to critically ill patients in intensive care unit for the management treatment of haemodynamic impairment, heart failure, septic cardiogenic shock, trauma among certain other diseases. In with vasopressors used induce vasoconstriction or enhance cardiac contractility. induces vasoconstriction, which causes systemic vascular resistance, leading i...
THE ADVENT of open-heart surgery has made available for the first time "f resh" bits of human heart muscle which can be used to study the protective effect of hypothermia on the recovery of contractility of muscle subjected to anoxic stress. There are a number of reports in the literature which demonstrate the tolerance of man and experimental animals to anoxia and varying degrees of hypothermi...
Augmentation index (AIx), a correlate of mortality, is thought to be influenced by left ventricular contractility and wave reflections. However, the relationship of AIx with left ventricular contractility changes has never been assessed, and the wave reflection theory has recently been questioned. This study sought to examine arterial waveform changes in response to reduced "wave reflection" an...
Amrinone, a bipyridine compound, has been shown to exert a positive inotropic effect on the heart, without producing cardiac arrhythmias. Because of preliminary observations suggesting that the actions of amrinone might change significantly with growth and development, we studied its effects on the contractility and electrophysiology of isolated cardiac muscle of 0to 96-day-old beagles and Purk...
Systolic heart failure (HF) is a systemic disease caused by reduced cardiac contractility. Although it would seem logical that this disease could be treated with strategies to directly improve contractility, inotropic therapies in the HF population have universally failed to live up to their expectations. Paradoxically, favorable outcomes can be achieved by administering drugs that may transien...
The PTEN/PI3K signaling pathway regulates a vast array of fundamental cellular responses. We show that cardiomyocyte-specific inactivation of tumor suppressor PTEN results in hypertrophy, and unexpectedly, a dramatic decrease in cardiac contractility. Analysis of double-mutant mice revealed that the cardiac hypertrophy and the contractility defects could be genetically uncoupled. PI3Kalpha medi...
• Congestive heart failure of the low output type may follow prolonged pressure and volume overload. This type of failure is most frequently defined clinically in terms of the variety of congestive syndromes which it produces. While there is no simple physiologic definition of failure, it is characterized by a defect in contractility wherein less work is performed at a given fiber length.' The ...
A cardioprotective response that alters ventricular contractility or promotes cardiomyocyte enlargement occurs with increased workload in conditions such as hypertension. When that response is excessive, pathological cardiac remodelling occurs, which can progress to heart failure, a leading cause of death worldwide. Mechanisms underlying this response are not fully understood. Here, we report t...
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